Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles

Lin Sun,1,2 Zeyu Liu,1 Zibei Lin,1 Dongmei Cun,3 Henry HY Tong,4 Ru Yan,1 Ruibing Wang,1 Ying Zheng1 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, People’s Republic of China;...

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Autores principales:	Sun L, Liu Z, Lin Z, Cun D, Tong HHY, Yan R, Wang R, Zheng Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Imiquimod-induced Psoriatic skin Pathological model Topical delivery Penetration Nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d061f91a4ce9432a9bfb00238011400f
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spelling	oai:doaj.org-article:d061f91a4ce9432a9bfb00238011400f2021-12-02T03:14:21ZComparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles1178-2013https://doaj.org/article/d061f91a4ce9432a9bfb00238011400f2018-09-01T00:00:00Zhttps://www.dovepress.com/comparison-of-normal-versus-imiquimod-induced-psoriatic-skin-in-mice-f-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Lin Sun,1,2 Zeyu Liu,1 Zibei Lin,1 Dongmei Cun,3 Henry HY Tong,4 Ru Yan,1 Ruibing Wang,1 Ying Zheng1 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, People’s Republic of China; 2Department of Pharmaceutical Sciences, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, 519041, People’s Republic of China; 3Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, People’s Republic of China; 4School of Health Sciences, Macao Polytechnic Institute, Macao Special Administrative Region, People’s Republic of China Background: As an immune-mediated skin disease, psoriasis encounters therapeutic challenges on topical drug development due to the unclear mechanism, and complicated morphological and physiological changes in the skin. Methods: In this study, imiquimod-induced psoriatic mouse skin (IMQ-psoriatic skin) was chosen as the in vitro pathological model to explore the penetration behaviors of drugs and nanoparticles (NPs). Results: Compared with normal skin, significantly higher penetration and skin accumulation were observed in IMQ-psoriatic skin for all the three model drugs. When poorly water-soluble curcumin was formulated as NPs that were subsequently loaded in gel, the drug’s penetration and accumulation in both normal and IMQ-psoriatic skins were significantly improved, in comparison with that of the curcumin suspension. Interestingly, the NPs’ size effect, in terms of their penetration and accumulation behaviors, was more pronounced for IMQ-psoriatic skin. Furthermore, by taking three sized FluoSpheres® as model NPs, confocal laser scanning microscopy demonstrated that the penetration pathways of NPs no longer followed the hair follicles channels, instead they were more widely distributed in the IMQ-psoriatic skin. Conclusion: In conclusion, the alternation of the IMQ-psoriatic skin structure will lead to the enhanced penetration of drug and NPs, and should be considered in topical drug formulation and further clinical practice for psoriasis therapy. Keywords: imiquimod-induced psoriatic skin, pathological model, topical delivery, penetration, nanoparticlesSun LLiu ZLin ZCun DTong HHYYan RWang RZheng YDove Medical PressarticleImiquimod-induced Psoriatic skinPathological modelTopical deliveryPenetrationNanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5625-5635 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Imiquimod-induced Psoriatic skin Pathological model Topical delivery Penetration Nanoparticles Medicine (General) R5-920
spellingShingle	Imiquimod-induced Psoriatic skin Pathological model Topical delivery Penetration Nanoparticles Medicine (General) R5-920 Sun L Liu Z Lin Z Cun D Tong HHY Yan R Wang R Zheng Y Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles
description	Lin Sun,1,2 Zeyu Liu,1 Zibei Lin,1 Dongmei Cun,3 Henry HY Tong,4 Ru Yan,1 Ruibing Wang,1 Ying Zheng1 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, People’s Republic of China; 2Department of Pharmaceutical Sciences, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, 519041, People’s Republic of China; 3Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, People’s Republic of China; 4School of Health Sciences, Macao Polytechnic Institute, Macao Special Administrative Region, People’s Republic of China Background: As an immune-mediated skin disease, psoriasis encounters therapeutic challenges on topical drug development due to the unclear mechanism, and complicated morphological and physiological changes in the skin. Methods: In this study, imiquimod-induced psoriatic mouse skin (IMQ-psoriatic skin) was chosen as the in vitro pathological model to explore the penetration behaviors of drugs and nanoparticles (NPs). Results: Compared with normal skin, significantly higher penetration and skin accumulation were observed in IMQ-psoriatic skin for all the three model drugs. When poorly water-soluble curcumin was formulated as NPs that were subsequently loaded in gel, the drug’s penetration and accumulation in both normal and IMQ-psoriatic skins were significantly improved, in comparison with that of the curcumin suspension. Interestingly, the NPs’ size effect, in terms of their penetration and accumulation behaviors, was more pronounced for IMQ-psoriatic skin. Furthermore, by taking three sized FluoSpheres® as model NPs, confocal laser scanning microscopy demonstrated that the penetration pathways of NPs no longer followed the hair follicles channels, instead they were more widely distributed in the IMQ-psoriatic skin. Conclusion: In conclusion, the alternation of the IMQ-psoriatic skin structure will lead to the enhanced penetration of drug and NPs, and should be considered in topical drug formulation and further clinical practice for psoriasis therapy. Keywords: imiquimod-induced psoriatic skin, pathological model, topical delivery, penetration, nanoparticles
format	article
author	Sun L Liu Z Lin Z Cun D Tong HHY Yan R Wang R Zheng Y
author_facet	Sun L Liu Z Lin Z Cun D Tong HHY Yan R Wang R Zheng Y
author_sort	Sun L
title	Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles
title_short	Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles
title_full	Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles
title_fullStr	Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles
title_full_unstemmed	Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles
title_sort	comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d061f91a4ce9432a9bfb00238011400f
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_version_	1718401886331076608

Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles

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