The role of stem cells in tumor targeting and growth suppression of gliomas

Hossein Eskandary1, Mohsen Basiri1, Seyed Noureddin Nematollahi-Mahani2, Sepideh Mehravaran31Neuroscience Research Center, 2Department of Anatomy, Afzalipour School of Medicine, Kerman University of Medical Sciences, 3Afzal Research Institute, Kerman, IranAbstract: Glioma remains the most challengin...

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Autores principales:	Eskandary H, Basiri M, Nematollahi-Mahani SN, Mehravaran S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d06240d3154a4597ad7c5a7f0ae45659
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spelling	oai:doaj.org-article:d06240d3154a4597ad7c5a7f0ae456592021-12-02T01:12:44ZThe role of stem cells in tumor targeting and growth suppression of gliomas1177-54751177-5491https://doaj.org/article/d06240d3154a4597ad7c5a7f0ae456592011-04-01T00:00:00Zhttp://www.dovepress.com/the-role-of-stem-cells-in-tumor-targeting-and-growth-suppression-of-gl-a6999https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Hossein Eskandary1, Mohsen Basiri1, Seyed Noureddin Nematollahi-Mahani2, Sepideh Mehravaran31Neuroscience Research Center, 2Department of Anatomy, Afzalipour School of Medicine, Kerman University of Medical Sciences, 3Afzal Research Institute, Kerman, IranAbstract: Glioma remains the most challenging solid organ tumor to treat successfully. Based on the capacity of stem cells to migrate extensively and target invading glioma cells, the transplantation of stem cells as a cell-based delivery system may provide additional tools for the treatment of gliomas. In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo. This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas. Based on these and further future data, clinical trials may be justified.Keywords: stem cell, brain tumor, glioma, tropism, growth suppression Eskandary HBasiri MNematollahi-Mahani SNMehravaran SDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2011, Iss default, Pp 61-70 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Eskandary H Basiri M Nematollahi-Mahani SN Mehravaran S The role of stem cells in tumor targeting and growth suppression of gliomas
description	Hossein Eskandary1, Mohsen Basiri1, Seyed Noureddin Nematollahi-Mahani2, Sepideh Mehravaran31Neuroscience Research Center, 2Department of Anatomy, Afzalipour School of Medicine, Kerman University of Medical Sciences, 3Afzal Research Institute, Kerman, IranAbstract: Glioma remains the most challenging solid organ tumor to treat successfully. Based on the capacity of stem cells to migrate extensively and target invading glioma cells, the transplantation of stem cells as a cell-based delivery system may provide additional tools for the treatment of gliomas. In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo. This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas. Based on these and further future data, clinical trials may be justified.Keywords: stem cell, brain tumor, glioma, tropism, growth suppression
format	article
author	Eskandary H Basiri M Nematollahi-Mahani SN Mehravaran S
author_facet	Eskandary H Basiri M Nematollahi-Mahani SN Mehravaran S
author_sort	Eskandary H
title	The role of stem cells in tumor targeting and growth suppression of gliomas
title_short	The role of stem cells in tumor targeting and growth suppression of gliomas
title_full	The role of stem cells in tumor targeting and growth suppression of gliomas
title_fullStr	The role of stem cells in tumor targeting and growth suppression of gliomas
title_full_unstemmed	The role of stem cells in tumor targeting and growth suppression of gliomas
title_sort	role of stem cells in tumor targeting and growth suppression of gliomas
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/d06240d3154a4597ad7c5a7f0ae45659
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The role of stem cells in tumor targeting and growth suppression of gliomas

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