Protective Role of Pharmacologic Postconditioning with Natural Honey on Myocardial Infarction Size

BACKGROUND AND OBJECTIVE: Honey has been noticed as an effective drug more than a nutrient. There is no report regarding cardioprotective effects of postconditioning with natural honey. In the present study, effects of postconditioning by honey on myocardial infarction size in ischemic-reperfused is...

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Autores principales:	M Najafi, A Gharakhani, H GHOYEMI, T Eteraf Oskouei
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	honey postconditioning infarction size isolated heart Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d06470a67eca4bf7b68ea74a2a52ad0d
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spelling	oai:doaj.org-article:d06470a67eca4bf7b68ea74a2a52ad0d2021-11-10T08:56:27ZProtective Role of Pharmacologic Postconditioning with Natural Honey on Myocardial Infarction Size1561-41072251-7170https://doaj.org/article/d06470a67eca4bf7b68ea74a2a52ad0d2011-03-01T00:00:00Zhttp://jbums.org/article-1-3735-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Honey has been noticed as an effective drug more than a nutrient. There is no report regarding cardioprotective effects of postconditioning with natural honey. In the present study, effects of postconditioning by honey on myocardial infarction size in ischemic-reperfused isolated rat heart were investigated.METHODS This experimental study was performed on 42 male Wistar rats weighing 270-330 g. The rats hearts were isolated and divided into five groups including a control and four postconditioning groups (n= 8-10 in each). The hearts were subjected to 30 min regional ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal Krebs-Henseleit (K/H) solution throughout the experiment, however in the postconditioning groups, they were perfused with honey (0.25, 0.5 and 1%) enriched K/H solution or glucose (equivalent concentration in 1% honey solution) from 10 min before to 10 min after reperfusion. To determine the infarct size, the hearts were perfused with Evans blue dye then cut into slices and incubated with triphenyltetrazolium chloride. Finally, the infarct size was determined by computerized planimetry.FINDINGS: Perfusion of isolated hearts with honey as a postconditioning agent significantly decreased infarct size and infarcted volume in the all treated groups. In the control group, the infarct size was 47±3%, however, natural honey (0.25, 0.5 and 1%) and glucose reduced it to 26±3, 6±3, 5±2 and 21±2 %, respectively (p<0.001 for all groups).CONCLUSION: The results showed protective effects of postconditioning by natural honey against ischemia-reperfusion injuries as reduction of infarction size. Probably, antioxidant activity of honey, scavenging of free radicals and the presence of energy sources in honey composition may involve in these protective effects.M NajafiA GharakhaniH GHOYEMIT Eteraf OskoueiBabol University of Medical Sciencesarticlehoneypostconditioninginfarction sizeisolated heartMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 2, Pp 12-18 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	honey postconditioning infarction size isolated heart Medicine R Medicine (General) R5-920
spellingShingle	honey postconditioning infarction size isolated heart Medicine R Medicine (General) R5-920 M Najafi A Gharakhani H GHOYEMI T Eteraf Oskouei Protective Role of Pharmacologic Postconditioning with Natural Honey on Myocardial Infarction Size
description	BACKGROUND AND OBJECTIVE: Honey has been noticed as an effective drug more than a nutrient. There is no report regarding cardioprotective effects of postconditioning with natural honey. In the present study, effects of postconditioning by honey on myocardial infarction size in ischemic-reperfused isolated rat heart were investigated.METHODS This experimental study was performed on 42 male Wistar rats weighing 270-330 g. The rats hearts were isolated and divided into five groups including a control and four postconditioning groups (n= 8-10 in each). The hearts were subjected to 30 min regional ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal Krebs-Henseleit (K/H) solution throughout the experiment, however in the postconditioning groups, they were perfused with honey (0.25, 0.5 and 1%) enriched K/H solution or glucose (equivalent concentration in 1% honey solution) from 10 min before to 10 min after reperfusion. To determine the infarct size, the hearts were perfused with Evans blue dye then cut into slices and incubated with triphenyltetrazolium chloride. Finally, the infarct size was determined by computerized planimetry.FINDINGS: Perfusion of isolated hearts with honey as a postconditioning agent significantly decreased infarct size and infarcted volume in the all treated groups. In the control group, the infarct size was 47±3%, however, natural honey (0.25, 0.5 and 1%) and glucose reduced it to 26±3, 6±3, 5±2 and 21±2 %, respectively (p<0.001 for all groups).CONCLUSION: The results showed protective effects of postconditioning by natural honey against ischemia-reperfusion injuries as reduction of infarction size. Probably, antioxidant activity of honey, scavenging of free radicals and the presence of energy sources in honey composition may involve in these protective effects.
format	article
author	M Najafi A Gharakhani H GHOYEMI T Eteraf Oskouei
author_facet	M Najafi A Gharakhani H GHOYEMI T Eteraf Oskouei
author_sort	M Najafi
title	Protective Role of Pharmacologic Postconditioning with Natural Honey on Myocardial Infarction Size
title_short	Protective Role of Pharmacologic Postconditioning with Natural Honey on Myocardial Infarction Size
title_full	Protective Role of Pharmacologic Postconditioning with Natural Honey on Myocardial Infarction Size
title_fullStr	Protective Role of Pharmacologic Postconditioning with Natural Honey on Myocardial Infarction Size
title_full_unstemmed	Protective Role of Pharmacologic Postconditioning with Natural Honey on Myocardial Infarction Size
title_sort	protective role of pharmacologic postconditioning with natural honey on myocardial infarction size
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/d06470a67eca4bf7b68ea74a2a52ad0d
work_keys_str_mv	AT mnajafi protectiveroleofpharmacologicpostconditioningwithnaturalhoneyonmyocardialinfarctionsize AT agharakhani protectiveroleofpharmacologicpostconditioningwithnaturalhoneyonmyocardialinfarctionsize AT hghoyemi protectiveroleofpharmacologicpostconditioningwithnaturalhoneyonmyocardialinfarctionsize AT teterafoskouei protectiveroleofpharmacologicpostconditioningwithnaturalhoneyonmyocardialinfarctionsize
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Protective Role of Pharmacologic Postconditioning with Natural Honey on Myocardial Infarction Size

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