Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and inflammatory (Gasdermin D) caspase activation.

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Autores principales:	Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri, Emad S. Alnemri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0672fa10e2747809092d92318838dba
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spelling	oai:doaj.org-article:d0672fa10e2747809092d92318838dba2021-12-02T14:39:00ZGasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation10.1038/s41467-019-09397-22041-1723https://doaj.org/article/d0672fa10e2747809092d92318838dba2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09397-2https://doaj.org/toc/2041-1723Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and inflammatory (Gasdermin D) caspase activation.Corey RogersDan A. ErkesAlexandria NardoneAndrew E. AplinTeresa Fernandes-AlnemriEmad S. AlnemriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Corey Rogers Dan A. Erkes Alexandria Nardone Andrew E. Aplin Teresa Fernandes-Alnemri Emad S. Alnemri Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
description	Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and inflammatory (Gasdermin D) caspase activation.
format	article
author	Corey Rogers Dan A. Erkes Alexandria Nardone Andrew E. Aplin Teresa Fernandes-Alnemri Emad S. Alnemri
author_facet	Corey Rogers Dan A. Erkes Alexandria Nardone Andrew E. Aplin Teresa Fernandes-Alnemri Emad S. Alnemri
author_sort	Corey Rogers
title	Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
title_short	Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
title_full	Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
title_fullStr	Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
title_full_unstemmed	Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
title_sort	gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d0672fa10e2747809092d92318838dba
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Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

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