Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl2 and CHX-ZnCl2 Particles

This work demonstrated for the first time the synthesis of novel chlorhexidine particles containing strontium and zinc, to provide an effective, affordable, and safe intervention in the treatment of recurrent infections found in Medicine and Dentistry. The CHX-SrCl2 and CHX-Zn...

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Autores principales:	Rui Sun, Jiaxin Zhang, Robert A. Whiley, Gleb B. Sukhorukov, Michael J. Cattell
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chlorhexidine drug delivery controlled release particulate delivery systems antibacterial Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d06b65a938ef4316945fc2c2410df21b
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spelling	oai:doaj.org-article:d06b65a938ef4316945fc2c2410df21b2021-11-25T18:40:46ZSynthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles10.3390/pharmaceutics131117991999-4923https://doaj.org/article/d06b65a938ef4316945fc2c2410df21b2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1799https://doaj.org/toc/1999-4923This work demonstrated for the first time the synthesis of novel chlorhexidine particles containing strontium and zinc, to provide an effective, affordable, and safe intervention in the treatment of recurrent infections found in Medicine and Dentistry. The CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> particles were synthesized by co-precipitation of chlorhexidine diacetate (CHXD) and zinc chloride or strontium chloride, where particle size was manipulated by controlling processing time and temperature. The CHX-ZnCl<sub>2</sub> and CHX-SrCl<sub>2</sub> particles were characterized using SEM, FTIR, and XRD. UV-Vis using artificial saliva (pH 4 and pH 7) was used to measure the drug release and ICP-OES ion release. The antibacterial properties were examined against <i>P. gingivalis</i>, <i>A. actinomycetemcomitans</i>, and <i>F. nucleatum subsp. Polymorphum</i>, and cytotoxicity was evaluated using mouse fibroblast L929 cells. The novel particles were as safe as commercial CHXD, with antibacterial activity against a range of oral pathogens. UV-Vis results run in artificial saliva (pH 4 and pH 7) indicated a higher release rate in acidic rather than neutral conditions. The CHX-ZnCl<sub>2</sub> particles provided the functionality of a smart Zinc and CHX release, with respect to environmental pH, allowing responsive antibacterial applications in the field of medicine and dentistry.Rui SunJiaxin ZhangRobert A. WhileyGleb B. SukhorukovMichael J. CattellMDPI AGarticlechlorhexidinedrug deliverycontrolled releaseparticulate delivery systemsantibacterialPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1799, p 1799 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chlorhexidine drug delivery controlled release particulate delivery systems antibacterial Pharmacy and materia medica RS1-441
spellingShingle	chlorhexidine drug delivery controlled release particulate delivery systems antibacterial Pharmacy and materia medica RS1-441 Rui Sun Jiaxin Zhang Robert A. Whiley Gleb B. Sukhorukov Michael J. Cattell Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles
description	This work demonstrated for the first time the synthesis of novel chlorhexidine particles containing strontium and zinc, to provide an effective, affordable, and safe intervention in the treatment of recurrent infections found in Medicine and Dentistry. The CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> particles were synthesized by co-precipitation of chlorhexidine diacetate (CHXD) and zinc chloride or strontium chloride, where particle size was manipulated by controlling processing time and temperature. The CHX-ZnCl<sub>2</sub> and CHX-SrCl<sub>2</sub> particles were characterized using SEM, FTIR, and XRD. UV-Vis using artificial saliva (pH 4 and pH 7) was used to measure the drug release and ICP-OES ion release. The antibacterial properties were examined against <i>P. gingivalis</i>, <i>A. actinomycetemcomitans</i>, and <i>F. nucleatum subsp. Polymorphum</i>, and cytotoxicity was evaluated using mouse fibroblast L929 cells. The novel particles were as safe as commercial CHXD, with antibacterial activity against a range of oral pathogens. UV-Vis results run in artificial saliva (pH 4 and pH 7) indicated a higher release rate in acidic rather than neutral conditions. The CHX-ZnCl<sub>2</sub> particles provided the functionality of a smart Zinc and CHX release, with respect to environmental pH, allowing responsive antibacterial applications in the field of medicine and dentistry.
format	article
author	Rui Sun Jiaxin Zhang Robert A. Whiley Gleb B. Sukhorukov Michael J. Cattell
author_facet	Rui Sun Jiaxin Zhang Robert A. Whiley Gleb B. Sukhorukov Michael J. Cattell
author_sort	Rui Sun
title	Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles
title_short	Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles
title_full	Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles
title_fullStr	Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles
title_full_unstemmed	Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles
title_sort	synthesis, drug release, and antibacterial properties of novel dendritic chx-srcl<sub>2</sub> and chx-zncl<sub>2</sub> particles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d06b65a938ef4316945fc2c2410df21b
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Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles

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