Methodological aspects of the acid hemodialysis concentrates development

The aim of this paper is to develop a scientifically based methodology for the development of acid concentrates in order to perform purposefully organized research on the implementation of these concentrates into industrial manufacture. Material and Methods. Methodological concept of acid concent...

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Autores principales:	A.M. Filipska, N.I. Hudz
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2020
Materias:	chronic kidney disease, methodology of pharmaceutical development, concentrates for hemodialysis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d06d4cef119d45ef89cec272596d6978
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spelling	oai:doaj.org-article:d06d4cef119d45ef89cec272596d69782021-11-10T19:49:51ZMethodological aspects of the acid hemodialysis concentrates development1029-42442415-330310.25040/aml2020.04.072https://doaj.org/article/d06d4cef119d45ef89cec272596d69782020-12-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/12https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303The aim of this paper is to develop a scientifically based methodology for the development of acid concentrates in order to perform purposefully organized research on the implementation of these concentrates into industrial manufacture. Material and Methods. Methodological concept of acid concentrates development. The objects of the study are liquid acid concentrates for hemodialysis containing sodium chloride, potassium chloride, calcium chloride hexahydrate, magnesium chloride hexahydrate, acetic acid and glucose. Methods of the study included bibliosemantic analysis, systematization of theoretical and practical material, and generalization of data. Results and Discussion. The methodology of the development of acid concentrates for hemodialysis is substantiated. To ensure the effectiveness and safety of the concentrates, it is necessary to theoretically and experimentally justify all pharmaceutical factors that affect the quality of the concentrates (active substances, solvent, technological processes, and packaging materials). The methodology of development of acid concentrates consists of the following stages of research: information retrieval, technological, analytical, and biological. The methodological concept is based on the implementation of the combination of marketing, technological, pharmacotechnological, physicochemical, chemical. and biopharmaceutical studies that ensure compliance of the developed products with medical, biological and pharmaceutical requirements for quality and safety of concentrates for renal replacement therapy. Conclusion.The authors developed and substantiated the methodology and drew up a plan of experimental research on the elaboration of the acid concentrates for renal replacement therapy in order to organize their industrial manufacture.A.M. FilipskaN.I. HudzDanylo Halytsky Lviv National Medical Universityarticlechronic kidney disease, methodology of pharmaceutical development, concentrates for hemodialysisMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 26, Iss 4, Pp 72-79 (2020)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	chronic kidney disease, methodology of pharmaceutical development, concentrates for hemodialysis Medicine (General) R5-920
spellingShingle	chronic kidney disease, methodology of pharmaceutical development, concentrates for hemodialysis Medicine (General) R5-920 A.M. Filipska N.I. Hudz Methodological aspects of the acid hemodialysis concentrates development
description	The aim of this paper is to develop a scientifically based methodology for the development of acid concentrates in order to perform purposefully organized research on the implementation of these concentrates into industrial manufacture. Material and Methods. Methodological concept of acid concentrates development. The objects of the study are liquid acid concentrates for hemodialysis containing sodium chloride, potassium chloride, calcium chloride hexahydrate, magnesium chloride hexahydrate, acetic acid and glucose. Methods of the study included bibliosemantic analysis, systematization of theoretical and practical material, and generalization of data. Results and Discussion. The methodology of the development of acid concentrates for hemodialysis is substantiated. To ensure the effectiveness and safety of the concentrates, it is necessary to theoretically and experimentally justify all pharmaceutical factors that affect the quality of the concentrates (active substances, solvent, technological processes, and packaging materials). The methodology of development of acid concentrates consists of the following stages of research: information retrieval, technological, analytical, and biological. The methodological concept is based on the implementation of the combination of marketing, technological, pharmacotechnological, physicochemical, chemical. and biopharmaceutical studies that ensure compliance of the developed products with medical, biological and pharmaceutical requirements for quality and safety of concentrates for renal replacement therapy. Conclusion.The authors developed and substantiated the methodology and drew up a plan of experimental research on the elaboration of the acid concentrates for renal replacement therapy in order to organize their industrial manufacture.
format	article
author	A.M. Filipska N.I. Hudz
author_facet	A.M. Filipska N.I. Hudz
author_sort	A.M. Filipska
title	Methodological aspects of the acid hemodialysis concentrates development
title_short	Methodological aspects of the acid hemodialysis concentrates development
title_full	Methodological aspects of the acid hemodialysis concentrates development
title_fullStr	Methodological aspects of the acid hemodialysis concentrates development
title_full_unstemmed	Methodological aspects of the acid hemodialysis concentrates development
title_sort	methodological aspects of the acid hemodialysis concentrates development
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2020
url	https://doaj.org/article/d06d4cef119d45ef89cec272596d6978
work_keys_str_mv	AT amfilipska methodologicalaspectsoftheacidhemodialysisconcentratesdevelopment AT nihudz methodologicalaspectsoftheacidhemodialysisconcentratesdevelopment
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Methodological aspects of the acid hemodialysis concentrates development

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