Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.

<h4>Objective</h4>The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.<h...

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Autores principales:	Diana J Leeming, Morten A Karsdal, Lars M Rasmussen, Alexandra Scholze, Martin Tepel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d070a02f42f74ecfbfd9c8f64a2cb9dd
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spelling	oai:doaj.org-article:d070a02f42f74ecfbfd9c8f64a2cb9dd2021-11-18T08:58:29ZAssociation of systemic collagen type IV formation with survival among patients undergoing hemodialysis.1932-620310.1371/journal.pone.0071050https://doaj.org/article/d070a02f42f74ecfbfd9c8f64a2cb9dd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23990924/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.<h4>Methods</h4>We performed an observational cohort study of 371 hemodialysis patients. Plasma P4NP_7S was analyzed using a specific enzyme-linked immunosorbent assay detecting the amino-terminal propeptide of type IV procollagen. Association between categories of plasma P4NP_7S concentrations and survival was initially assessed by Kaplan-Meier analysis, then in an adjusted Cox model.<h4>Results</h4>For hemodialysis patients in the highest category of systemic collagen type IV formation, i.e. plasma P4NP_7S concentrations more than 775 pg/L, an increased risk for death was observed (highest P4NP_7S category vs all other categories, hazard ratio, 1.934; 95% confidence interval, 1.139 to 3.285). Survival analysis showed an increased risk of death in the highest P4NP_7S category compared to the other categories (Chi square 6.903; P = 0.032). Median survival was only 105 days in the highest P4NP_7S category whereas it was 629 days in the medium category, and 905 days in the lowest category. Multivariable-adjusted Cox regression showed increased odds for death with higher age and higher P4NP_7S categories. Systemic collagen type IV formation was associated with plasma concentrations of the collagen IV degradation product C4M (Spearman r = 0.764; P<0.0001) confirming extracellular matrix turnover.<h4>Conclusion</h4>Among hemodialysis patients elevated systemic collagen type IV formation suggesting accelerating systemic fibrosis was associated with increased risk of death.Diana J LeemingMorten A KarsdalLars M RasmussenAlexandra ScholzeMartin TepelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71050 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Diana J Leeming Morten A Karsdal Lars M Rasmussen Alexandra Scholze Martin Tepel Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.
description	<h4>Objective</h4>The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.<h4>Methods</h4>We performed an observational cohort study of 371 hemodialysis patients. Plasma P4NP_7S was analyzed using a specific enzyme-linked immunosorbent assay detecting the amino-terminal propeptide of type IV procollagen. Association between categories of plasma P4NP_7S concentrations and survival was initially assessed by Kaplan-Meier analysis, then in an adjusted Cox model.<h4>Results</h4>For hemodialysis patients in the highest category of systemic collagen type IV formation, i.e. plasma P4NP_7S concentrations more than 775 pg/L, an increased risk for death was observed (highest P4NP_7S category vs all other categories, hazard ratio, 1.934; 95% confidence interval, 1.139 to 3.285). Survival analysis showed an increased risk of death in the highest P4NP_7S category compared to the other categories (Chi square 6.903; P = 0.032). Median survival was only 105 days in the highest P4NP_7S category whereas it was 629 days in the medium category, and 905 days in the lowest category. Multivariable-adjusted Cox regression showed increased odds for death with higher age and higher P4NP_7S categories. Systemic collagen type IV formation was associated with plasma concentrations of the collagen IV degradation product C4M (Spearman r = 0.764; P<0.0001) confirming extracellular matrix turnover.<h4>Conclusion</h4>Among hemodialysis patients elevated systemic collagen type IV formation suggesting accelerating systemic fibrosis was associated with increased risk of death.
format	article
author	Diana J Leeming Morten A Karsdal Lars M Rasmussen Alexandra Scholze Martin Tepel
author_facet	Diana J Leeming Morten A Karsdal Lars M Rasmussen Alexandra Scholze Martin Tepel
author_sort	Diana J Leeming
title	Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.
title_short	Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.
title_full	Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.
title_fullStr	Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.
title_full_unstemmed	Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.
title_sort	association of systemic collagen type iv formation with survival among patients undergoing hemodialysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d070a02f42f74ecfbfd9c8f64a2cb9dd
work_keys_str_mv	AT dianajleeming associationofsystemiccollagentypeivformationwithsurvivalamongpatientsundergoinghemodialysis AT mortenakarsdal associationofsystemiccollagentypeivformationwithsurvivalamongpatientsundergoinghemodialysis AT larsmrasmussen associationofsystemiccollagentypeivformationwithsurvivalamongpatientsundergoinghemodialysis AT alexandrascholze associationofsystemiccollagentypeivformationwithsurvivalamongpatientsundergoinghemodialysis AT martintepel associationofsystemiccollagentypeivformationwithsurvivalamongpatientsundergoinghemodialysis
_version_	1718421111257956352

Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.

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