Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke

Chen Qin,1,* Xiuli Yan,1,* Hang Jin,1 Ruyi Zhang,2 Yaode He,1 Xin Sun,1 Yihe Zhang,1 Zhen-Ni Guo,1,3 Yi Yang1,3 1Department of Neurology, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 2Department of Cardiovascular Center, The First Hospital of Jilin...

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Autores principales:	Qin C, Yan X, Jin H, Zhang R, He Y, Sun X, Zhang Y, Guo ZN, Yang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	remote ischemic conditioning cerebral hemodynamics ischemic stroke cerebral blood flow Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d0734e58f3544476b5b3d5b4d386870c
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spelling	oai:doaj.org-article:d0734e58f3544476b5b3d5b4d386870c2021-12-02T05:11:59ZEffects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke1178-2021https://doaj.org/article/d0734e58f3544476b5b3d5b4d386870c2020-01-01T00:00:00Zhttps://www.dovepress.com/effects-of-remote-ischemic-conditioning-on-cerebral-hemodynamics-in-is-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chen Qin,1,* Xiuli Yan,1,* Hang Jin,1 Ruyi Zhang,2 Yaode He,1 Xin Sun,1 Yihe Zhang,1 Zhen-Ni Guo,1,3 Yi Yang1,3 1Department of Neurology, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 2Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 3Clinical Trial and Research Center for Stroke, Department of Neurology, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Yang; Zhen-Ni GuoDepartment of Neurology, The First Hospital of Jilin University, Xinmin Street 1#, Changchun 130021, People’s Republic of ChinaTel +86-13756661217; +86-18186872986Fax +86-431-88782378; +86-431-88782378Email doctoryangyi@163.com; zhen1ni2@163.comAbstract: Ischemic stroke is one of the most common cerebrovascular diseases and is the leading cause of disability all over the world. It is well known that cerebral blood flow (CBF) is disturbed or even disrupted when ischemic stroke happens. The imbalance between demand and shortage of blood supply makes ischemic stroke take place or worsen. The search for treatments that can preserve CBF, especially during the acute phase of ischemic stroke, has become a research hotspot. Animal and clinical experiments have proven that remote ischemic conditioning (RIC) is a beneficial therapeutic strategy for the treatment of ischemic stroke. However, the mechanism by which RIC affects CBF has not been fully understood. This review aims to discuss several possible mechanisms of RIC on the cerebral hemodynamics in ischemic stroke, such as the improvement of cardiac function and collateral circulation of cerebral vessels, the protection of neurovascular units, the formation of gas molecules, the effect on the function of vascular endothelial cells and the nervous system. RIC has the potential to become a therapeutic treatment to improve CBF in ischemic stroke. Future studies are needed to highlight our understanding of RIC as well as accelerate its clinical translation.Keywords: remote ischemic conditioning, cerebral hemodynamics, ischemic stroke, cerebral blood flow  Qin CYan XJin HZhang RHe YSun XZhang YGuo ZNYang YDove Medical Pressarticleremote ischemic conditioningcerebral hemodynamicsischemic strokecerebral blood flowNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 283-299 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	remote ischemic conditioning cerebral hemodynamics ischemic stroke cerebral blood flow Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	remote ischemic conditioning cerebral hemodynamics ischemic stroke cerebral blood flow Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Qin C Yan X Jin H Zhang R He Y Sun X Zhang Y Guo ZN Yang Y Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke
description	Chen Qin,1,* Xiuli Yan,1,* Hang Jin,1 Ruyi Zhang,2 Yaode He,1 Xin Sun,1 Yihe Zhang,1 Zhen-Ni Guo,1,3 Yi Yang1,3 1Department of Neurology, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 2Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 3Clinical Trial and Research Center for Stroke, Department of Neurology, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Yang; Zhen-Ni GuoDepartment of Neurology, The First Hospital of Jilin University, Xinmin Street 1#, Changchun 130021, People’s Republic of ChinaTel +86-13756661217; +86-18186872986Fax +86-431-88782378; +86-431-88782378Email doctoryangyi@163.com; zhen1ni2@163.comAbstract: Ischemic stroke is one of the most common cerebrovascular diseases and is the leading cause of disability all over the world. It is well known that cerebral blood flow (CBF) is disturbed or even disrupted when ischemic stroke happens. The imbalance between demand and shortage of blood supply makes ischemic stroke take place or worsen. The search for treatments that can preserve CBF, especially during the acute phase of ischemic stroke, has become a research hotspot. Animal and clinical experiments have proven that remote ischemic conditioning (RIC) is a beneficial therapeutic strategy for the treatment of ischemic stroke. However, the mechanism by which RIC affects CBF has not been fully understood. This review aims to discuss several possible mechanisms of RIC on the cerebral hemodynamics in ischemic stroke, such as the improvement of cardiac function and collateral circulation of cerebral vessels, the protection of neurovascular units, the formation of gas molecules, the effect on the function of vascular endothelial cells and the nervous system. RIC has the potential to become a therapeutic treatment to improve CBF in ischemic stroke. Future studies are needed to highlight our understanding of RIC as well as accelerate its clinical translation.Keywords: remote ischemic conditioning, cerebral hemodynamics, ischemic stroke, cerebral blood flow
format	article
author	Qin C Yan X Jin H Zhang R He Y Sun X Zhang Y Guo ZN Yang Y
author_facet	Qin C Yan X Jin H Zhang R He Y Sun X Zhang Y Guo ZN Yang Y
author_sort	Qin C
title	Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke
title_short	Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke
title_full	Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke
title_fullStr	Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke
title_full_unstemmed	Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke
title_sort	effects of remote ischemic conditioning on cerebral hemodynamics in ischemic stroke
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d0734e58f3544476b5b3d5b4d386870c
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Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke

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