Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population.

<h4>Background</h4>Chronic alcohol use is a risk factor for non-cardia gastric adenocarcinoma. However, it is less well understood whether alcohol use is a risk factor for premalignant mucosal changes, namely gastric intestinal metaplasia. We examined the association between various para...

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Autores principales:	Hudson M Holmes, Andre G Jove, Mimi C Tan, Hashem B El-Serag, Aaron P Thrift
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d073b2610c184fc4a7603ec6d180f238
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spelling	oai:doaj.org-article:d073b2610c184fc4a7603ec6d180f2382021-12-02T20:13:05ZAlcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population.1932-620310.1371/journal.pone.0260019https://doaj.org/article/d073b2610c184fc4a7603ec6d180f2382021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260019https://doaj.org/toc/1932-6203<h4>Background</h4>Chronic alcohol use is a risk factor for non-cardia gastric adenocarcinoma. However, it is less well understood whether alcohol use is a risk factor for premalignant mucosal changes, namely gastric intestinal metaplasia. We examined the association between various parameters of alcohol use and risk of gastric intestinal metaplasia.<h4>Methods</h4>We used data from 2084 participants (including 403 with gastric intestinal metaplasia) recruited between February 2008-August 2013 into a cross-sectional study at the Michael E. DeBakey Veterans Affairs Medical Center in Houston, Texas. All participants underwent a study upper endoscopy with systematic gastric mapping biopsies. Cases had intestinal metaplasia on any non-cardia gastric biopsy. Participants self-reported lifetime history of alcohol consumption, along with other lifestyle risk factors, through a study survey. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for categories of average alcohol consumption using multivariable logistic regression, and restricted cubic spline regression to explore the potential shape of a dose-response relationship.<h4>Results</h4>Compared to lifelong non-drinkers, individuals who consumed on average ≥28 drinks per week had no elevated risk for gastric intestinal metaplasia (adjusted OR, 1.27; 95% CI, 0.74-2.19). Based on a spline regression curve and its 95% CI, there was also no demonstrable association between cumulative lifetime alcohol consumption and risk of gastric intestinal metaplasia. Similarly, we found no association between beverage type (beer, wine, liquor/spirits) and risk for gastric intestinal metaplasia.<h4>Conclusions</h4>Neither amount of alcohol consumed nor specific beverage type was associated with risk of gastric intestinal metaplasia.Hudson M HolmesAndre G JoveMimi C TanHashem B El-SeragAaron P ThriftPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260019 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hudson M Holmes Andre G Jove Mimi C Tan Hashem B El-Serag Aaron P Thrift Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population.
description	<h4>Background</h4>Chronic alcohol use is a risk factor for non-cardia gastric adenocarcinoma. However, it is less well understood whether alcohol use is a risk factor for premalignant mucosal changes, namely gastric intestinal metaplasia. We examined the association between various parameters of alcohol use and risk of gastric intestinal metaplasia.<h4>Methods</h4>We used data from 2084 participants (including 403 with gastric intestinal metaplasia) recruited between February 2008-August 2013 into a cross-sectional study at the Michael E. DeBakey Veterans Affairs Medical Center in Houston, Texas. All participants underwent a study upper endoscopy with systematic gastric mapping biopsies. Cases had intestinal metaplasia on any non-cardia gastric biopsy. Participants self-reported lifetime history of alcohol consumption, along with other lifestyle risk factors, through a study survey. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for categories of average alcohol consumption using multivariable logistic regression, and restricted cubic spline regression to explore the potential shape of a dose-response relationship.<h4>Results</h4>Compared to lifelong non-drinkers, individuals who consumed on average ≥28 drinks per week had no elevated risk for gastric intestinal metaplasia (adjusted OR, 1.27; 95% CI, 0.74-2.19). Based on a spline regression curve and its 95% CI, there was also no demonstrable association between cumulative lifetime alcohol consumption and risk of gastric intestinal metaplasia. Similarly, we found no association between beverage type (beer, wine, liquor/spirits) and risk for gastric intestinal metaplasia.<h4>Conclusions</h4>Neither amount of alcohol consumed nor specific beverage type was associated with risk of gastric intestinal metaplasia.
format	article
author	Hudson M Holmes Andre G Jove Mimi C Tan Hashem B El-Serag Aaron P Thrift
author_facet	Hudson M Holmes Andre G Jove Mimi C Tan Hashem B El-Serag Aaron P Thrift
author_sort	Hudson M Holmes
title	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population.
title_short	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population.
title_full	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population.
title_fullStr	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population.
title_full_unstemmed	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population.
title_sort	alcohol consumption and the risk of gastric intestinal metaplasia in a u.s. veterans population.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d073b2610c184fc4a7603ec6d180f238
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Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population.

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