Association between levels of vitamin D and inflammatory markers in healthy women

Fawaz Azizieh,1 Khulood O Alyahya,2 Raj Raghupathy3 1Department of Mathematics and Natural Sciences, Gulf University for Science and Technology, Kuwait City, Kuwait; 2Science Department, College of Basic Education, Public Authority for Applied Education and Training, Kuwait City, Kuwait; 3Department...

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Autores principales:	Azizieh F, Alyahya KO, Raghupathy R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Vitamin D Cytokines Adult women CRP Kuwait. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d075183570ac4da58b1612e1607fb7e6
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spelling	oai:doaj.org-article:d075183570ac4da58b1612e1607fb7e62021-12-02T06:23:03ZAssociation between levels of vitamin D and inflammatory markers in healthy women1178-7031https://doaj.org/article/d075183570ac4da58b1612e1607fb7e62016-04-01T00:00:00Zhttps://www.dovepress.com/association-between-levels-of-vitamin-d-and-inflammatory-markers-in-he-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Fawaz Azizieh,1 Khulood O Alyahya,2 Raj Raghupathy3 1Department of Mathematics and Natural Sciences, Gulf University for Science and Technology, Kuwait City, Kuwait; 2Science Department, College of Basic Education, Public Authority for Applied Education and Training, Kuwait City, Kuwait; 3Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait Background: No one can deny that the biological importance of vitamin D is much beyond its classical role in bone metabolism. Several recent publications have highlighted its potential role in the functioning of the immune system. The overall objective of this study was to look into possible correlations between levels of vitamin D and inflammatory markers in sera of healthy adult women. These markers included proinflammatory cytokines (interleukin [IL]-1β, IL-6, IL-8, IL-17, interferon [IFN]-γ, and tumor necrosis factor [TNF]-α), anti-inflammatory cytokines (IL-4, IL-10, and IL-13), as well as C-reactive protein (CRP) as a general indicator of inflammation. Methods: Venous blood samples were collected from 118 healthy adult women and serum levels of vitamin D, CRP, proinflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, IFN-γ, and TNF-α), and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were measured. Results: There were no significant direct correlations between serum levels of vitamin D and any of the inflammatory markers measured. However, subjects with deficient levels of vitamin D and high CRP produced significantly higher levels of the proinflammatory cytokines (TNF-α and IL-8) as compared to subjects with low CRP levels with nondeficient and deficient levels of vitamin D. Further, the anti-inflammatory/proinflammatory ratios suggest a role of vitamin D in maintaining an anti-inflammatory environment at low levels of CRP, an association that is weaker at high CRP levels in subjects with subclinical inflammatory situations. Conclusion: These data point to a possible role of vitamin D as a contributing factor in balancing cytokines toward an anti-inflammatory role in inflammatory situations. Keywords: vitamin D, cytokines, adult women, CRP, KuwaitAzizieh FAlyahya KORaghupathy RDove Medical PressarticleVitamin DCytokinesAdult womenCRPKuwait.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2016, Iss Issue 1, Pp 51-57 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vitamin D Cytokines Adult women CRP Kuwait. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Vitamin D Cytokines Adult women CRP Kuwait. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Azizieh F Alyahya KO Raghupathy R Association between levels of vitamin D and inflammatory markers in healthy women
description	Fawaz Azizieh,1 Khulood O Alyahya,2 Raj Raghupathy3 1Department of Mathematics and Natural Sciences, Gulf University for Science and Technology, Kuwait City, Kuwait; 2Science Department, College of Basic Education, Public Authority for Applied Education and Training, Kuwait City, Kuwait; 3Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait Background: No one can deny that the biological importance of vitamin D is much beyond its classical role in bone metabolism. Several recent publications have highlighted its potential role in the functioning of the immune system. The overall objective of this study was to look into possible correlations between levels of vitamin D and inflammatory markers in sera of healthy adult women. These markers included proinflammatory cytokines (interleukin [IL]-1β, IL-6, IL-8, IL-17, interferon [IFN]-γ, and tumor necrosis factor [TNF]-α), anti-inflammatory cytokines (IL-4, IL-10, and IL-13), as well as C-reactive protein (CRP) as a general indicator of inflammation. Methods: Venous blood samples were collected from 118 healthy adult women and serum levels of vitamin D, CRP, proinflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, IFN-γ, and TNF-α), and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were measured. Results: There were no significant direct correlations between serum levels of vitamin D and any of the inflammatory markers measured. However, subjects with deficient levels of vitamin D and high CRP produced significantly higher levels of the proinflammatory cytokines (TNF-α and IL-8) as compared to subjects with low CRP levels with nondeficient and deficient levels of vitamin D. Further, the anti-inflammatory/proinflammatory ratios suggest a role of vitamin D in maintaining an anti-inflammatory environment at low levels of CRP, an association that is weaker at high CRP levels in subjects with subclinical inflammatory situations. Conclusion: These data point to a possible role of vitamin D as a contributing factor in balancing cytokines toward an anti-inflammatory role in inflammatory situations. Keywords: vitamin D, cytokines, adult women, CRP, Kuwait
format	article
author	Azizieh F Alyahya KO Raghupathy R
author_facet	Azizieh F Alyahya KO Raghupathy R
author_sort	Azizieh F
title	Association between levels of vitamin D and inflammatory markers in healthy women
title_short	Association between levels of vitamin D and inflammatory markers in healthy women
title_full	Association between levels of vitamin D and inflammatory markers in healthy women
title_fullStr	Association between levels of vitamin D and inflammatory markers in healthy women
title_full_unstemmed	Association between levels of vitamin D and inflammatory markers in healthy women
title_sort	association between levels of vitamin d and inflammatory markers in healthy women
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/d075183570ac4da58b1612e1607fb7e6
work_keys_str_mv	AT aziziehf associationbetweenlevelsofvitamindandinflammatorymarkersinhealthywomen AT alyahyako associationbetweenlevelsofvitamindandinflammatorymarkersinhealthywomen AT raghupathyr associationbetweenlevelsofvitamindandinflammatorymarkersinhealthywomen
_version_	1718399963095891968

Association between levels of vitamin D and inflammatory markers in healthy women

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