Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

T-cell activation upon antigen stimulation is essential for the continuation of the adaptive immune response. Impairment of mitochondrial oxidative phosphorylation is a well-known disruptor of T-cell activation. Dihydroorotate dehydrogenase (DHODH) is a component of the de novo synthesis of pyrimidi...

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Bibliographic Details
Main Authors: Marlies J. W. Peeters, Pia Aehnlich, Adriano Pizzella, Kasper Mølgaard, Tina Seremet, Özcan Met, Lene Juel Rasmussen, Per thor Straten, Claus Desler
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
T-cell metabolism
T-cell activation
pyrimidine de novo synthesis
mitochondrial respiration and oxidative respiration
immunosenescence and exhaustion
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/d07890576b8949e18e9b8caa7c3ef5cf
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https://doaj.org/article/d07890576b8949e18e9b8caa7c3ef5cf

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