Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study

Background: Although respiratory distress syndrome (RDS) constitutes a postnatal risk factor for bleeding and thromboembolic events in neonates, few studies have addressed this issue. We aimed to evaluate the hemostatic profile of neonates with RDS using rotational thromboelastometry (ROTEM). Method...

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Autores principales:	Georgios N. Katsaras, Rozeta Sokou, Andreas G. Tsantes, Aikaterini Konstantinidi, Dimitra Gialamprinou, Daniele Piovani, Stefanos Bonovas, Anastasios G. Kriebardis, Georgios Mitsiakos, Styliani Kokoris, Argirios E. Tsantes
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	respiratory distress syndrome infant newborn thromboelastometry Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d07c783f597c4c9a96f204a492fe1054
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spelling	oai:doaj.org-article:d07c783f597c4c9a96f204a492fe10542021-11-25T17:20:35ZThromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study10.3390/diagnostics111119952075-4418https://doaj.org/article/d07c783f597c4c9a96f204a492fe10542021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1995https://doaj.org/toc/2075-4418Background: Although respiratory distress syndrome (RDS) constitutes a postnatal risk factor for bleeding and thromboembolic events in neonates, few studies have addressed this issue. We aimed to evaluate the hemostatic profile of neonates with RDS using rotational thromboelastometry (ROTEM). Methods: An observational study was conducted from November 2018 to November 2020 in the NICU of General Hospital of Nikaia “Aghios Panteleimon”. Preterm and term neonates with RDS hospitalized in the NICU were included and EXTEM (tissue factor-triggered extrinsic pathway), INTEM (ellagic acid activated intrinsic pathway), and FIBTEM (with platelet inhibitor cytochalasin D) assays were performed at the onset of the disease. Results: A hypocoagulable profile was noted in neonates with RDS compared to controls, expressed as significant prolongation of EXTEM CT (clotting time) and CFT (clot formation time), lower EXTEM A10 (amplitude at 10 min), MCF (maximum clot firmness), and LI60 (lysis index). Furthermore, prolongation of INTEM CFT and FIBTEM CT, and decreased INTEM and FIBTEM A10 and MCF were found in neonates with RDS. Multivariable logistic regression analysis showed that RDS is an independent factor for the recorded alterations in ROTEM variables. Conclusions: RDS is associated with a hypocoagulable profile and greater hyperfibrinolytic potential compared to healthy neonates.Georgios N. KatsarasRozeta SokouAndreas G. TsantesAikaterini KonstantinidiDimitra GialamprinouDaniele PiovaniStefanos BonovasAnastasios G. KriebardisGeorgios MitsiakosStyliani KokorisArgirios E. TsantesMDPI AGarticlerespiratory distress syndromeinfantnewbornthromboelastometryMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1995, p 1995 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	respiratory distress syndrome infant newborn thromboelastometry Medicine (General) R5-920
spellingShingle	respiratory distress syndrome infant newborn thromboelastometry Medicine (General) R5-920 Georgios N. Katsaras Rozeta Sokou Andreas G. Tsantes Aikaterini Konstantinidi Dimitra Gialamprinou Daniele Piovani Stefanos Bonovas Anastasios G. Kriebardis Georgios Mitsiakos Styliani Kokoris Argirios E. Tsantes Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study
description	Background: Although respiratory distress syndrome (RDS) constitutes a postnatal risk factor for bleeding and thromboembolic events in neonates, few studies have addressed this issue. We aimed to evaluate the hemostatic profile of neonates with RDS using rotational thromboelastometry (ROTEM). Methods: An observational study was conducted from November 2018 to November 2020 in the NICU of General Hospital of Nikaia “Aghios Panteleimon”. Preterm and term neonates with RDS hospitalized in the NICU were included and EXTEM (tissue factor-triggered extrinsic pathway), INTEM (ellagic acid activated intrinsic pathway), and FIBTEM (with platelet inhibitor cytochalasin D) assays were performed at the onset of the disease. Results: A hypocoagulable profile was noted in neonates with RDS compared to controls, expressed as significant prolongation of EXTEM CT (clotting time) and CFT (clot formation time), lower EXTEM A10 (amplitude at 10 min), MCF (maximum clot firmness), and LI60 (lysis index). Furthermore, prolongation of INTEM CFT and FIBTEM CT, and decreased INTEM and FIBTEM A10 and MCF were found in neonates with RDS. Multivariable logistic regression analysis showed that RDS is an independent factor for the recorded alterations in ROTEM variables. Conclusions: RDS is associated with a hypocoagulable profile and greater hyperfibrinolytic potential compared to healthy neonates.
format	article
author	Georgios N. Katsaras Rozeta Sokou Andreas G. Tsantes Aikaterini Konstantinidi Dimitra Gialamprinou Daniele Piovani Stefanos Bonovas Anastasios G. Kriebardis Georgios Mitsiakos Styliani Kokoris Argirios E. Tsantes
author_facet	Georgios N. Katsaras Rozeta Sokou Andreas G. Tsantes Aikaterini Konstantinidi Dimitra Gialamprinou Daniele Piovani Stefanos Bonovas Anastasios G. Kriebardis Georgios Mitsiakos Styliani Kokoris Argirios E. Tsantes
author_sort	Georgios N. Katsaras
title	Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study
title_short	Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study
title_full	Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study
title_fullStr	Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study
title_full_unstemmed	Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study
title_sort	thromboelastometry in neonates with respiratory distress syndrome: a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d07c783f597c4c9a96f204a492fe1054
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_version_	1718412496951312384

Thromboelastometry in Neonates with Respiratory Distress Syndrome: A Pilot Study

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