A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Humans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) inf...

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Autores principales: Kaustubh Adhikari, Macarena Fuentes-Guajardo, Mirsha Quinto-Sánchez, Javier Mendoza-Revilla, Juan Camilo Chacón-Duque, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria- Cátira Bortolini, Samuel Canizales-Quinteros, Michael Cheeseman, Javier Rosique, Gabriel Bedoya, Francisco Rothhammer, Denis Headon, Rolando González-José, David Balding, Andrés Ruiz-Linares
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/d07cc19f3fa148309d99800133b88ddc
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spelling oai:doaj.org-article:d07cc19f3fa148309d99800133b88ddc2021-12-02T15:34:58ZA genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation10.1038/ncomms116162041-1723https://doaj.org/article/d07cc19f3fa148309d99800133b88ddc2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11616https://doaj.org/toc/2041-1723Humans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) influencing nose morphology.Kaustubh AdhikariMacarena Fuentes-GuajardoMirsha Quinto-SánchezJavier Mendoza-RevillaJuan Camilo Chacón-DuqueVictor Acuña-AlonzoClaudia JaramilloWilliam AriasRodrigo Barquera LozanoGastón Macín PérezJorge Gómez-ValdésHugo Villamil-RamírezTábita HunemeierVirginia RamalloCaio C. Silva de CerqueiraMalena HurtadoValeria VillegasVanessa GranjaCarla GalloGiovanni PolettiLavinia Schuler-FacciniFrancisco M. SalzanoMaria- Cátira BortoliniSamuel Canizales-QuinterosMichael CheesemanJavier RosiqueGabriel BedoyaFrancisco RothhammerDenis HeadonRolando González-JoséDavid BaldingAndrés Ruiz-LinaresNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kaustubh Adhikari
Macarena Fuentes-Guajardo
Mirsha Quinto-Sánchez
Javier Mendoza-Revilla
Juan Camilo Chacón-Duque
Victor Acuña-Alonzo
Claudia Jaramillo
William Arias
Rodrigo Barquera Lozano
Gastón Macín Pérez
Jorge Gómez-Valdés
Hugo Villamil-Ramírez
Tábita Hunemeier
Virginia Ramallo
Caio C. Silva de Cerqueira
Malena Hurtado
Valeria Villegas
Vanessa Granja
Carla Gallo
Giovanni Poletti
Lavinia Schuler-Faccini
Francisco M. Salzano
Maria- Cátira Bortolini
Samuel Canizales-Quinteros
Michael Cheeseman
Javier Rosique
Gabriel Bedoya
Francisco Rothhammer
Denis Headon
Rolando González-José
David Balding
Andrés Ruiz-Linares
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
description Humans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) influencing nose morphology.
format article
author Kaustubh Adhikari
Macarena Fuentes-Guajardo
Mirsha Quinto-Sánchez
Javier Mendoza-Revilla
Juan Camilo Chacón-Duque
Victor Acuña-Alonzo
Claudia Jaramillo
William Arias
Rodrigo Barquera Lozano
Gastón Macín Pérez
Jorge Gómez-Valdés
Hugo Villamil-Ramírez
Tábita Hunemeier
Virginia Ramallo
Caio C. Silva de Cerqueira
Malena Hurtado
Valeria Villegas
Vanessa Granja
Carla Gallo
Giovanni Poletti
Lavinia Schuler-Faccini
Francisco M. Salzano
Maria- Cátira Bortolini
Samuel Canizales-Quinteros
Michael Cheeseman
Javier Rosique
Gabriel Bedoya
Francisco Rothhammer
Denis Headon
Rolando González-José
David Balding
Andrés Ruiz-Linares
author_facet Kaustubh Adhikari
Macarena Fuentes-Guajardo
Mirsha Quinto-Sánchez
Javier Mendoza-Revilla
Juan Camilo Chacón-Duque
Victor Acuña-Alonzo
Claudia Jaramillo
William Arias
Rodrigo Barquera Lozano
Gastón Macín Pérez
Jorge Gómez-Valdés
Hugo Villamil-Ramírez
Tábita Hunemeier
Virginia Ramallo
Caio C. Silva de Cerqueira
Malena Hurtado
Valeria Villegas
Vanessa Granja
Carla Gallo
Giovanni Poletti
Lavinia Schuler-Faccini
Francisco M. Salzano
Maria- Cátira Bortolini
Samuel Canizales-Quinteros
Michael Cheeseman
Javier Rosique
Gabriel Bedoya
Francisco Rothhammer
Denis Headon
Rolando González-José
David Balding
Andrés Ruiz-Linares
author_sort Kaustubh Adhikari
title A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_short A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_full A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_fullStr A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_full_unstemmed A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_sort genome-wide association scan implicates dchs2, runx2, gli3, pax1 and edar in human facial variation
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/d07cc19f3fa148309d99800133b88ddc
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