Acetylation regulates ribonucleotide reductase activity and cancer cell growth

Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are modulated by acetylation and deacetylation of RRM2 b...

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Autores principales:	Guo Chen, Yin Luo, Kurt Warncke, Youwei Sun, David S. Yu, Haian Fu, Madhusmita Behera, Suresh S. Ramalingam, Paul W. Doetsch, Duc M. Duong, Michael Lammers, Walter J. Curran, Xingming Deng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d07d654e84db43299a467240e28b6a80
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spelling	oai:doaj.org-article:d07d654e84db43299a467240e28b6a802021-12-02T17:01:38ZAcetylation regulates ribonucleotide reductase activity and cancer cell growth10.1038/s41467-019-11214-92041-1723https://doaj.org/article/d07d654e84db43299a467240e28b6a802019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11214-9https://doaj.org/toc/2041-1723Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are modulated by acetylation and deacetylation of RRM2 by KAT7 and Sirt2 respectively.Guo ChenYin LuoKurt WarnckeYouwei SunDavid S. YuHaian FuMadhusmita BeheraSuresh S. RamalingamPaul W. DoetschDuc M. DuongMichael LammersWalter J. CurranXingming DengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guo Chen Yin Luo Kurt Warncke Youwei Sun David S. Yu Haian Fu Madhusmita Behera Suresh S. Ramalingam Paul W. Doetsch Duc M. Duong Michael Lammers Walter J. Curran Xingming Deng Acetylation regulates ribonucleotide reductase activity and cancer cell growth
description	Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are modulated by acetylation and deacetylation of RRM2 by KAT7 and Sirt2 respectively.
format	article
author	Guo Chen Yin Luo Kurt Warncke Youwei Sun David S. Yu Haian Fu Madhusmita Behera Suresh S. Ramalingam Paul W. Doetsch Duc M. Duong Michael Lammers Walter J. Curran Xingming Deng
author_facet	Guo Chen Yin Luo Kurt Warncke Youwei Sun David S. Yu Haian Fu Madhusmita Behera Suresh S. Ramalingam Paul W. Doetsch Duc M. Duong Michael Lammers Walter J. Curran Xingming Deng
author_sort	Guo Chen
title	Acetylation regulates ribonucleotide reductase activity and cancer cell growth
title_short	Acetylation regulates ribonucleotide reductase activity and cancer cell growth
title_full	Acetylation regulates ribonucleotide reductase activity and cancer cell growth
title_fullStr	Acetylation regulates ribonucleotide reductase activity and cancer cell growth
title_full_unstemmed	Acetylation regulates ribonucleotide reductase activity and cancer cell growth
title_sort	acetylation regulates ribonucleotide reductase activity and cancer cell growth
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d07d654e84db43299a467240e28b6a80
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_version_	1718382114177548288

Acetylation regulates ribonucleotide reductase activity and cancer cell growth

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