Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups

Pentacyclic triterpenoids (PTs) functionalized at the D/E rings possess a wide spectrum of biological activities but are poorly accessible. Here, the authors report a site-selective C-H hydroxylation at the D/E rings of PTs by exploiting transient pyridine-imino directing groups and disclose the syn...

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Autores principales:	Tong Mu, Bingcheng Wei, Dapeng Zhu, Biao Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d07d846c1edc4ef99870d29e0afea441
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spelling	oai:doaj.org-article:d07d846c1edc4ef99870d29e0afea4412021-12-02T19:09:20ZSite-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups10.1038/s41467-020-18138-92041-1723https://doaj.org/article/d07d846c1edc4ef99870d29e0afea4412020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18138-9https://doaj.org/toc/2041-1723Pentacyclic triterpenoids (PTs) functionalized at the D/E rings possess a wide spectrum of biological activities but are poorly accessible. Here, the authors report a site-selective C-H hydroxylation at the D/E rings of PTs by exploiting transient pyridine-imino directing groups and disclose the synthesis of related natural products.Tong MuBingcheng WeiDapeng ZhuBiao YuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tong Mu Bingcheng Wei Dapeng Zhu Biao Yu Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups
description	Pentacyclic triterpenoids (PTs) functionalized at the D/E rings possess a wide spectrum of biological activities but are poorly accessible. Here, the authors report a site-selective C-H hydroxylation at the D/E rings of PTs by exploiting transient pyridine-imino directing groups and disclose the synthesis of related natural products.
format	article
author	Tong Mu Bingcheng Wei Dapeng Zhu Biao Yu
author_facet	Tong Mu Bingcheng Wei Dapeng Zhu Biao Yu
author_sort	Tong Mu
title	Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups
title_short	Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups
title_full	Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups
title_fullStr	Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups
title_full_unstemmed	Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups
title_sort	site-selective c-h hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d07d846c1edc4ef99870d29e0afea441
work_keys_str_mv	AT tongmu siteselectivechhydroxylationofpentacyclictriterpenoidsdirectedbytransientchiralpyridineiminogroups AT bingchengwei siteselectivechhydroxylationofpentacyclictriterpenoidsdirectedbytransientchiralpyridineiminogroups AT dapengzhu siteselectivechhydroxylationofpentacyclictriterpenoidsdirectedbytransientchiralpyridineiminogroups AT biaoyu siteselectivechhydroxylationofpentacyclictriterpenoidsdirectedbytransientchiralpyridineiminogroups
_version_	1718377118019092480

Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups

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