Anti‐obesity activity of Heracleum moellendorffii root extracts in 3T3‐L1 adipocytes

Abstract It has been reported that H. mollendorffii roots (HMR) have various pharmacological activities such as anti‐inflammatory activity and immunostimulatory activity. However, the anti‐obesity activity of HMR has not been studied. Thus, we evaluated in vitro anti‐obesity of HMR in mouse preadipo...

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Autores principales:	Na Gyeong Geum, Ho Jun Son, Joo Ho Yeo, Ju Hyeong Yu, Min Yeong Choi, Jae Won Lee, Jueng Kyu Baek, Jin Boo Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Adipocytes adipogenesis anti‐obesity activity differentiation heracleum moellendorffii root Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/d07d8f7800ee41cf9ff182902f745c68
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spelling	oai:doaj.org-article:d07d8f7800ee41cf9ff182902f745c682021-11-04T13:06:42ZAnti‐obesity activity of Heracleum moellendorffii root extracts in 3T3‐L1 adipocytes2048-717710.1002/fsn3.2487https://doaj.org/article/d07d8f7800ee41cf9ff182902f745c682021-11-01T00:00:00Zhttps://doi.org/10.1002/fsn3.2487https://doaj.org/toc/2048-7177Abstract It has been reported that H. mollendorffii roots (HMR) have various pharmacological activities such as anti‐inflammatory activity and immunostimulatory activity. However, the anti‐obesity activity of HMR has not been studied. Thus, we evaluated in vitro anti‐obesity of HMR in mouse preadipocytes, 3T3‐L1 cells. HMR reduced the lipid accumulation and triglyceride (TG) contents in 3T3‐L1 cells. HMR inhibited the protein expressions such as CCAAT/enhancer‐binding protein alpha (CEBPα), peroxisome proliferator‐activated receptor gamma (PPARγ), perilipin‐1, adiponectin, fatty acid‐binding protein 4 (FABP4), fatty acid synthase (FAS), and acetyl‐CoA carboxylase (ACC) related to the lipid accumulation of the mature adipocytes. In addition, HMR induced the proteasomal degradation of CEBPα related to the differentiation of the preadipocytes into the mature adipocytes by activating c‐Jun N‐terminal kinases (JNK) and glycogen synthase kinase 3 beta (GSK3β). Based on the results of this study, HMR inhibited the differentiation of preadipocytes into mature adipocytes through the CEBPα degradation via JNK and GSK3β activation and subsequently blocked lipid accumulation of mature adipocytes through inhibiting lipid accumulation‐related proteins such as CEBPα, PPARγ, perilipin‐1, adiponectin, FABP4, FAS, and ACC.Na Gyeong GeumHo Jun SonJoo Ho YeoJu Hyeong YuMin Yeong ChoiJae Won LeeJueng Kyu BaekJin Boo JeongWileyarticleAdipocytesadipogenesisanti‐obesity activitydifferentiationheracleum moellendorffii rootNutrition. Foods and food supplyTX341-641ENFood Science & Nutrition, Vol 9, Iss 11, Pp 5939-5945 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adipocytes adipogenesis anti‐obesity activity differentiation heracleum moellendorffii root Nutrition. Foods and food supply TX341-641
spellingShingle	Adipocytes adipogenesis anti‐obesity activity differentiation heracleum moellendorffii root Nutrition. Foods and food supply TX341-641 Na Gyeong Geum Ho Jun Son Joo Ho Yeo Ju Hyeong Yu Min Yeong Choi Jae Won Lee Jueng Kyu Baek Jin Boo Jeong Anti‐obesity activity of Heracleum moellendorffii root extracts in 3T3‐L1 adipocytes
description	Abstract It has been reported that H. mollendorffii roots (HMR) have various pharmacological activities such as anti‐inflammatory activity and immunostimulatory activity. However, the anti‐obesity activity of HMR has not been studied. Thus, we evaluated in vitro anti‐obesity of HMR in mouse preadipocytes, 3T3‐L1 cells. HMR reduced the lipid accumulation and triglyceride (TG) contents in 3T3‐L1 cells. HMR inhibited the protein expressions such as CCAAT/enhancer‐binding protein alpha (CEBPα), peroxisome proliferator‐activated receptor gamma (PPARγ), perilipin‐1, adiponectin, fatty acid‐binding protein 4 (FABP4), fatty acid synthase (FAS), and acetyl‐CoA carboxylase (ACC) related to the lipid accumulation of the mature adipocytes. In addition, HMR induced the proteasomal degradation of CEBPα related to the differentiation of the preadipocytes into the mature adipocytes by activating c‐Jun N‐terminal kinases (JNK) and glycogen synthase kinase 3 beta (GSK3β). Based on the results of this study, HMR inhibited the differentiation of preadipocytes into mature adipocytes through the CEBPα degradation via JNK and GSK3β activation and subsequently blocked lipid accumulation of mature adipocytes through inhibiting lipid accumulation‐related proteins such as CEBPα, PPARγ, perilipin‐1, adiponectin, FABP4, FAS, and ACC.
format	article
author	Na Gyeong Geum Ho Jun Son Joo Ho Yeo Ju Hyeong Yu Min Yeong Choi Jae Won Lee Jueng Kyu Baek Jin Boo Jeong
author_facet	Na Gyeong Geum Ho Jun Son Joo Ho Yeo Ju Hyeong Yu Min Yeong Choi Jae Won Lee Jueng Kyu Baek Jin Boo Jeong
author_sort	Na Gyeong Geum
title	Anti‐obesity activity of Heracleum moellendorffii root extracts in 3T3‐L1 adipocytes
title_short	Anti‐obesity activity of Heracleum moellendorffii root extracts in 3T3‐L1 adipocytes
title_full	Anti‐obesity activity of Heracleum moellendorffii root extracts in 3T3‐L1 adipocytes
title_fullStr	Anti‐obesity activity of Heracleum moellendorffii root extracts in 3T3‐L1 adipocytes
title_full_unstemmed	Anti‐obesity activity of Heracleum moellendorffii root extracts in 3T3‐L1 adipocytes
title_sort	anti‐obesity activity of heracleum moellendorffii root extracts in 3t3‐l1 adipocytes
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/d07d8f7800ee41cf9ff182902f745c68
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Anti‐obesity activity of Heracleum moellendorffii root extracts in 3T3‐L1 adipocytes

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