Fox Serum Proteomics Analysis Suggests Host-Specific Responses to Angiostrongylus vasorum Infection in Canids

Dogs infected with the cardiopulmonary nematode Angiostrongylus vasorum may suffer from respiratory distress and/or bleeding disorders. Descriptions of clinical signs in foxes are rare, despite high prevalence. To evaluate the impact of infection on coagulation and immune response...

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Autores principales:	Nina Gillis-Germitsch, Tobias Kockmann, Christian M. O. Kapel, Stig M. Thamsborg, Pia Webster, Lucienne Tritten, Manuela Schnyder
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Angiostrongylus vasorum</i> proteomics fox <i>Vulpes vulpes</i> immune response coagulation Medicine R
Acceso en línea:	https://doaj.org/article/d07f381772334ff3962d4c5933ce9988
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spelling	oai:doaj.org-article:d07f381772334ff3962d4c5933ce99882021-11-25T18:38:51ZFox Serum Proteomics Analysis Suggests Host-Specific Responses to <i>Angiostrongylus</i> <i>v</i><i>asorum</i> Infection in Canids10.3390/pathogens101115132076-0817https://doaj.org/article/d07f381772334ff3962d4c5933ce99882021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1513https://doaj.org/toc/2076-0817Dogs infected with the cardiopulmonary nematode <i>Angiostrongylus vasorum</i> may suffer from respiratory distress and/or bleeding disorders. Descriptions of clinical signs in foxes are rare, despite high prevalence. To evaluate the impact of infection on coagulation and immune response, serum proteins from eight experimentally infected foxes before and after inoculation (day 0, 35, 84, 154) were subjected to differential proteomic analyses based on quantitative data and compared to available data from dogs. The number of proteins with differential abundance compared to the uninfected baseline increased with chronicity of infection. Bone marrow proteoglycan, chitinase 3-like protein 1 and pulmonary surfactant-associated protein B were among the most prominently increased proteins. The abundance of several proteins involved in coagulation was decreased. Enriched pathways obtained from both increased and decreased proteins included, among others, “platelet degranulation” and “haemostasis”, and indicated both activation and suppression of coagulation. Qualitative comparison to dog data suggests some parallel serum proteomic alterations. The comparison, however, also indicates that foxes have a more adequate immunopathological response to <i>A. vasorum</i> infection compared to dogs, facilitating persistent infections in foxes. Our findings imply that foxes may be more tolerant to <i>A. vasorum</i> infection, as compared to dogs, reflecting a longer evolutionary host–parasite adaptation in foxes, which constitute a key wildlife reservoir.Nina Gillis-GermitschTobias KockmannChristian M. O. KapelStig M. ThamsborgPia WebsterLucienne TrittenManuela SchnyderMDPI AGarticle<i>Angiostrongylus vasorum</i>proteomicsfox<i>Vulpes vulpes</i>immune responsecoagulationMedicineRENPathogens, Vol 10, Iss 1513, p 1513 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Angiostrongylus vasorum</i> proteomics fox <i>Vulpes vulpes</i> immune response coagulation Medicine R
spellingShingle	<i>Angiostrongylus vasorum</i> proteomics fox <i>Vulpes vulpes</i> immune response coagulation Medicine R Nina Gillis-Germitsch Tobias Kockmann Christian M. O. Kapel Stig M. Thamsborg Pia Webster Lucienne Tritten Manuela Schnyder Fox Serum Proteomics Analysis Suggests Host-Specific Responses to <i>Angiostrongylus</i> <i>v</i><i>asorum</i> Infection in Canids
description	Dogs infected with the cardiopulmonary nematode <i>Angiostrongylus vasorum</i> may suffer from respiratory distress and/or bleeding disorders. Descriptions of clinical signs in foxes are rare, despite high prevalence. To evaluate the impact of infection on coagulation and immune response, serum proteins from eight experimentally infected foxes before and after inoculation (day 0, 35, 84, 154) were subjected to differential proteomic analyses based on quantitative data and compared to available data from dogs. The number of proteins with differential abundance compared to the uninfected baseline increased with chronicity of infection. Bone marrow proteoglycan, chitinase 3-like protein 1 and pulmonary surfactant-associated protein B were among the most prominently increased proteins. The abundance of several proteins involved in coagulation was decreased. Enriched pathways obtained from both increased and decreased proteins included, among others, “platelet degranulation” and “haemostasis”, and indicated both activation and suppression of coagulation. Qualitative comparison to dog data suggests some parallel serum proteomic alterations. The comparison, however, also indicates that foxes have a more adequate immunopathological response to <i>A. vasorum</i> infection compared to dogs, facilitating persistent infections in foxes. Our findings imply that foxes may be more tolerant to <i>A. vasorum</i> infection, as compared to dogs, reflecting a longer evolutionary host–parasite adaptation in foxes, which constitute a key wildlife reservoir.
format	article
author	Nina Gillis-Germitsch Tobias Kockmann Christian M. O. Kapel Stig M. Thamsborg Pia Webster Lucienne Tritten Manuela Schnyder
author_facet	Nina Gillis-Germitsch Tobias Kockmann Christian M. O. Kapel Stig M. Thamsborg Pia Webster Lucienne Tritten Manuela Schnyder
author_sort	Nina Gillis-Germitsch
title	Fox Serum Proteomics Analysis Suggests Host-Specific Responses to <i>Angiostrongylus</i> <i>v</i><i>asorum</i> Infection in Canids
title_short	Fox Serum Proteomics Analysis Suggests Host-Specific Responses to <i>Angiostrongylus</i> <i>v</i><i>asorum</i> Infection in Canids
title_full	Fox Serum Proteomics Analysis Suggests Host-Specific Responses to <i>Angiostrongylus</i> <i>v</i><i>asorum</i> Infection in Canids
title_fullStr	Fox Serum Proteomics Analysis Suggests Host-Specific Responses to <i>Angiostrongylus</i> <i>v</i><i>asorum</i> Infection in Canids
title_full_unstemmed	Fox Serum Proteomics Analysis Suggests Host-Specific Responses to <i>Angiostrongylus</i> <i>v</i><i>asorum</i> Infection in Canids
title_sort	fox serum proteomics analysis suggests host-specific responses to <i>angiostrongylus</i> <i>v</i><i>asorum</i> infection in canids
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d07f381772334ff3962d4c5933ce9988
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Fox Serum Proteomics Analysis Suggests Host-Specific Responses to <i>Angiostrongylus</i> <i>v</i><i>asorum</i> Infection in Canids

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