Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

Abstract The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis...

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Autores principales:	Nevsun Inanc, Gonca Mumcu, Meryem Can, Meral Yay, Angelika Silbereisen, Daniel Manoil, Haner Direskeneli, Nagihan Bostanci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d081977f23a5415cb3ef15474fc08bcf
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spelling	oai:doaj.org-article:d081977f23a5415cb3ef15474fc08bcf2021-12-02T14:06:12ZElevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis10.1038/s41598-021-82335-92045-2322https://doaj.org/article/d081977f23a5415cb3ef15474fc08bcf2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82335-9https://doaj.org/toc/2045-2322Abstract The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis.Nevsun InancGonca MumcuMeryem CanMeral YayAngelika SilbereisenDaniel ManoilHaner DireskeneliNagihan BostanciNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nevsun Inanc Gonca Mumcu Meryem Can Meral Yay Angelika Silbereisen Daniel Manoil Haner Direskeneli Nagihan Bostanci Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
description	Abstract The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis.
format	article
author	Nevsun Inanc Gonca Mumcu Meryem Can Meral Yay Angelika Silbereisen Daniel Manoil Haner Direskeneli Nagihan Bostanci
author_facet	Nevsun Inanc Gonca Mumcu Meryem Can Meral Yay Angelika Silbereisen Daniel Manoil Haner Direskeneli Nagihan Bostanci
author_sort	Nevsun Inanc
title	Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_short	Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_full	Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_fullStr	Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_full_unstemmed	Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis
title_sort	elevated serum trem-1 is associated with periodontitis and disease activity in rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d081977f23a5415cb3ef15474fc08bcf
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Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

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