From Academia to the Market – Air-stable Ni(ii)/Josiphos Catalysts

The design, synthesis, commercialization and application of air-stable Ni(II)/Josiphos complexes has been realized in a collaboration between Solvias and ICBMS (University Lyon 1). The Ni-complexes are utilized as versatile precatalysts for diverse cross-coupling reactions. Apart from being active i...

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Autores principales: Florian Bächle, Achim Link, Abderrahmane Amgoune, Anis Tlili
Formato: article
Lenguaje:DE
EN
FR
Publicado: Swiss Chemical Society 2021
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Acceso en línea:https://doaj.org/article/d082c265a9ac46e7948ebc179da9eca9
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Sumario:The design, synthesis, commercialization and application of air-stable Ni(II)/Josiphos complexes has been realized in a collaboration between Solvias and ICBMS (University Lyon 1). The Ni-complexes are utilized as versatile precatalysts for diverse cross-coupling reactions. Apart from being active in established C–C and C–N couplings at low catalyst loadings, the novel Ni-precatalysts enabled the development of the challenging monoarylation of ammonia, ammonia surrogates and even alkylammonium chlorides with aryl carbamates. Finally, the α-arylation of acetone with aryl chlorides, carbamates and pivalates was demonstrated using the Ni(II)/Josiphos precatalysts.