Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia

Suhua Huang,1 Fuqing Zhou,2,3 Jian Jiang,2,3 Muhua Huang,2,3 Xianjun Zeng,2,3 Shan Ding,1 Honghan Gong2,3 1Department of Radiology, Jiangxi Province Children’s Hospital, 2Department of Radiology, The First Affiliated Hospital, Nanchang University, 3Jiangxi Province Medical Imaging Researc...

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Autores principales:	Huang S, Zhou F, Jiang J, Huang M, Zeng X, Ding S, Gong H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	functional connectivity strength disconnection chronic primary insomnia sleep disorders resting-state fMRI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d0834eca0fd8497aa549a0ab79e63317
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spelling	oai:doaj.org-article:d0834eca0fd8497aa549a0ab79e633172021-12-02T09:06:40ZRegional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia1178-2021https://doaj.org/article/d0834eca0fd8497aa549a0ab79e633172017-06-01T00:00:00Zhttps://www.dovepress.com/regional-impairment-of-intrinsic-functional-connectivity-strength-in-p-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Suhua Huang,1 Fuqing Zhou,2,3 Jian Jiang,2,3 Muhua Huang,2,3 Xianjun Zeng,2,3 Shan Ding,1 Honghan Gong2,3 1Department of Radiology, Jiangxi Province Children’s Hospital, 2Department of Radiology, The First Affiliated Hospital, Nanchang University, 3Jiangxi Province Medical Imaging Research Institute, Nanchang, People’s Republic of China Abstract: Several neuroimaging studies have suggested that brain impairment and plasticity occur in patients with chronic primary insomnia (CPI); however, the effects of insomnia on the intrinsic organization of the brain remain largely unknown. In this study, a voxel-based functional connectivity strength (FCS) assessment, a data-driven method based on a theoretical approach, was applied to investigate the effects of insomnia on the intrinsic organization of the whole brain in 27 treatment-naïve CPI patients and 26 well-matched healthy controls (HCs). Compared with HCs, CPI patients exhibited decreased FCS primarily in the right dorsolateral prefrontal cortex, the right medial prefrontal cortex (MPFC), the left basal ganglia/insula, and the right cerebellum anterior lobe (CAL) due to decreased functional connectivity patterns. These results suggest that poor sleep quality could impair FCS within the brain, including the MPFC and the CAL, which are important for cognitive control and modulating motor and limbic functions. Additionally, a receiver operator characteristic analysis revealed that altered FCS has moderate sensitivity (76.9%–88.5%) and specificity (59.3%–70.4%) as a reference indicator to discriminate CPI patients from HCs. Taken together, these findings provide evidence for abnormal intrinsic brain activity in CPI patients and might improve our understanding of the pathophysiological processes that occur in insomnia patients. Keywords: functional connectivity strength, disconnection, chronic primary insomnia, sleep disorders, resting-state fMRIHuang SZhou FJiang JHuang MZeng XDing SGong HDove Medical Pressarticlefunctional connectivity strengthdisconnectionchronic primary insomniasleep disordersresting-state fMRINeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1449-1462 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	functional connectivity strength disconnection chronic primary insomnia sleep disorders resting-state fMRI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	functional connectivity strength disconnection chronic primary insomnia sleep disorders resting-state fMRI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Huang S Zhou F Jiang J Huang M Zeng X Ding S Gong H Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia
description	Suhua Huang,1 Fuqing Zhou,2,3 Jian Jiang,2,3 Muhua Huang,2,3 Xianjun Zeng,2,3 Shan Ding,1 Honghan Gong2,3 1Department of Radiology, Jiangxi Province Children’s Hospital, 2Department of Radiology, The First Affiliated Hospital, Nanchang University, 3Jiangxi Province Medical Imaging Research Institute, Nanchang, People’s Republic of China Abstract: Several neuroimaging studies have suggested that brain impairment and plasticity occur in patients with chronic primary insomnia (CPI); however, the effects of insomnia on the intrinsic organization of the brain remain largely unknown. In this study, a voxel-based functional connectivity strength (FCS) assessment, a data-driven method based on a theoretical approach, was applied to investigate the effects of insomnia on the intrinsic organization of the whole brain in 27 treatment-naïve CPI patients and 26 well-matched healthy controls (HCs). Compared with HCs, CPI patients exhibited decreased FCS primarily in the right dorsolateral prefrontal cortex, the right medial prefrontal cortex (MPFC), the left basal ganglia/insula, and the right cerebellum anterior lobe (CAL) due to decreased functional connectivity patterns. These results suggest that poor sleep quality could impair FCS within the brain, including the MPFC and the CAL, which are important for cognitive control and modulating motor and limbic functions. Additionally, a receiver operator characteristic analysis revealed that altered FCS has moderate sensitivity (76.9%–88.5%) and specificity (59.3%–70.4%) as a reference indicator to discriminate CPI patients from HCs. Taken together, these findings provide evidence for abnormal intrinsic brain activity in CPI patients and might improve our understanding of the pathophysiological processes that occur in insomnia patients. Keywords: functional connectivity strength, disconnection, chronic primary insomnia, sleep disorders, resting-state fMRI
format	article
author	Huang S Zhou F Jiang J Huang M Zeng X Ding S Gong H
author_facet	Huang S Zhou F Jiang J Huang M Zeng X Ding S Gong H
author_sort	Huang S
title	Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia
title_short	Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia
title_full	Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia
title_fullStr	Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia
title_full_unstemmed	Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia
title_sort	regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d0834eca0fd8497aa549a0ab79e63317
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_version_	1718398271895896064

Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia

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