Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cell Hi-C data.
Single-cell Hi-C (scHi-C) interrogates genome-wide chromatin interaction in individual cells, allowing us to gain insights into 3D genome organization. However, the extremely sparse nature of scHi-C data poses a significant barrier to analysis, limiting our ability to tease out hidden biological inf...
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| Auteurs principaux: | , , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2020
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/d087140ff4c3496697afe98471225fab |
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