Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>

Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to <named-content content-type="genus-species">Streptococcus pneumoniae</named-content>

ABSTRACT Both intracellular immune sensing and extracellular innate immune sensing have been implicated in initiating macrophage proinflammatory cytokine responses to Streptococcus pneumoniae. The S. pneumoniae capsule, a major virulence determinant, prevents phagocytosis, and we hypothesized that t...

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Bibliographic Details
Main Authors: Jimstan Periselneris, Giuseppe Ercoli, Tracey Pollard, Suneeta Chimalapati, Emilie Camberlein, Gabriella Szylar, Catherine Hyams, Gillian Tomlinson, Fernanda C. Petersen, R. Andres Floto, Mahdad Noursadeghi, Jeremy S. Brown
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
Streptococcus pneumoniae
capsule
TLR2
inflammation
Microbiology
QR1-502
Online Access:https://doaj.org/article/d089ef97c70043238d89741d49e77722
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