Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus

Background: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation o...

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Autores principales:	Ali A. Dawood, Mahmood A. A. Altobje, Zeyad T. Alrassam
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	elisa gpt got bsf-2 hbsag Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d08b5f1330c6481a8eed548316af0320
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spelling	oai:doaj.org-article:d08b5f1330c6481a8eed548316af03202021-11-18T08:03:50ZElevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus1563-06252313-741X10.15789/1563-0625-EOB-2091https://doaj.org/article/d08b5f1330c6481a8eed548316af03202021-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2091https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XBackground: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation of the human immune response. Objective: this report aims to estimate the BSF-2, GPT, and GOT levels in patients’ serum with different stages of hepatitis B compared with healthy control. Methods: This study assessed 52 patients presumably with acute and chronic cases who have HBsAg positive. BSF-2 was detected using ELISA assay. Biochemical parameters were determined using kits of an automated analyzer. SPSS version-16 software was used for statistical analysis. Results: Acute hepatitis B patients had shown elevation in BSF-2 level more than of chronic hepatitis B. GPT and GOT levels elevated in the acute hepatitis group more than of the chronic hepatitis group. We reported a significant value between BSF-2, GOT, and GPT levels. We didn’t score an association between patient’s age and cases groups of hepatitis. Conclusion: our data confirmed increasing of BSF-2 levels with the increase of GOT level more than GPT level with acute hepatitis B. BSF-2, GPT and GOT levels are varied in different courses of acute and chronic HBV. We surmised that the elevation of BSF-2 levels designates liver injury of patients with acute HBV.Ali A. DawoodMahmood A. A. AltobjeZeyad T. AlrassamSPb RAACIarticleelisagptgotbsf-2hbsagImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 1, Pp 87-94 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	elisa gpt got bsf-2 hbsag Immunologic diseases. Allergy RC581-607
spellingShingle	elisa gpt got bsf-2 hbsag Immunologic diseases. Allergy RC581-607 Ali A. Dawood Mahmood A. A. Altobje Zeyad T. Alrassam Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus
description	Background: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation of the human immune response. Objective: this report aims to estimate the BSF-2, GPT, and GOT levels in patients’ serum with different stages of hepatitis B compared with healthy control. Methods: This study assessed 52 patients presumably with acute and chronic cases who have HBsAg positive. BSF-2 was detected using ELISA assay. Biochemical parameters were determined using kits of an automated analyzer. SPSS version-16 software was used for statistical analysis. Results: Acute hepatitis B patients had shown elevation in BSF-2 level more than of chronic hepatitis B. GPT and GOT levels elevated in the acute hepatitis group more than of the chronic hepatitis group. We reported a significant value between BSF-2, GOT, and GPT levels. We didn’t score an association between patient’s age and cases groups of hepatitis. Conclusion: our data confirmed increasing of BSF-2 levels with the increase of GOT level more than GPT level with acute hepatitis B. BSF-2, GPT and GOT levels are varied in different courses of acute and chronic HBV. We surmised that the elevation of BSF-2 levels designates liver injury of patients with acute HBV.
format	article
author	Ali A. Dawood Mahmood A. A. Altobje Zeyad T. Alrassam
author_facet	Ali A. Dawood Mahmood A. A. Altobje Zeyad T. Alrassam
author_sort	Ali A. Dawood
title	Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus
title_short	Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus
title_full	Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus
title_fullStr	Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus
title_full_unstemmed	Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus
title_sort	elevation of bsf-2 level in serum of patients with hepatitis b virus
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/d08b5f1330c6481a8eed548316af0320
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Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus

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