Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.

<h4>Background and objective</h4>A number of studies have focused on the association between oral contraceptive (OC), hormonal replacement therapy (HRT) and reproductive factors and meningioma risk, but the results were inconsistent. Thus, a meta-analysis was performed to obtain more pre...

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Autores principales:	Zhen-Yu Qi, Chuan Shao, Yu-Lun Huang, Guo-Zhen Hui, You-Xin Zhou, Zhong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d093ec7438e54402bdfb8b7614527aff
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spelling	oai:doaj.org-article:d093ec7438e54402bdfb8b7614527aff2021-11-18T08:40:11ZReproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.1932-620310.1371/journal.pone.0083261https://doaj.org/article/d093ec7438e54402bdfb8b7614527aff2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386167/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and objective</h4>A number of studies have focused on the association between oral contraceptive (OC), hormonal replacement therapy (HRT) and reproductive factors and meningioma risk, but the results were inconsistent. Thus, a meta-analysis was performed to obtain more precise estimates of risk.<h4>Methods</h4>We conducted a literature search using PubMed and EMBASE databases to July 2013, without any limitations. Random effects models were used to summarize results.<h4>Results</h4>Twelve case-control and six cohort studies were included in this meta-analysis. We found that an increased risk of meningioma was associated with HRT use(RR = 1.19, 95% CI = 1.01-1.40), postmenopausal women(RR = 1.32, 95% CI = 1.07-1.64) and parity(RR = 1.18, 95% CI = 1.00-1.40).No significant associations were observed for OC use (RR = 0.93, 95% CI = 0.83-1.03), age at menarche(RR = 1.06, 95% CI = 0.92-1.21), age at menopause(RR = 1.03, 95% CI = 0.81-1.30), or age at first birth(RR = 0.94, 95% CI = 0.80-1.10).<h4>Conclusion</h4>In conclusion, the results of our study support the hypothesis that longer exposure to effect of female sex hormones may increase the risk of meningioma in women, yet additional studies are warranted to confirm our findings and identify the underlying biological mechanisms.Zhen-Yu QiChuan ShaoYu-Lun HuangGuo-Zhen HuiYou-Xin ZhouZhong WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83261 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhen-Yu Qi Chuan Shao Yu-Lun Huang Guo-Zhen Hui You-Xin Zhou Zhong Wang Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.
description	<h4>Background and objective</h4>A number of studies have focused on the association between oral contraceptive (OC), hormonal replacement therapy (HRT) and reproductive factors and meningioma risk, but the results were inconsistent. Thus, a meta-analysis was performed to obtain more precise estimates of risk.<h4>Methods</h4>We conducted a literature search using PubMed and EMBASE databases to July 2013, without any limitations. Random effects models were used to summarize results.<h4>Results</h4>Twelve case-control and six cohort studies were included in this meta-analysis. We found that an increased risk of meningioma was associated with HRT use(RR = 1.19, 95% CI = 1.01-1.40), postmenopausal women(RR = 1.32, 95% CI = 1.07-1.64) and parity(RR = 1.18, 95% CI = 1.00-1.40).No significant associations were observed for OC use (RR = 0.93, 95% CI = 0.83-1.03), age at menarche(RR = 1.06, 95% CI = 0.92-1.21), age at menopause(RR = 1.03, 95% CI = 0.81-1.30), or age at first birth(RR = 0.94, 95% CI = 0.80-1.10).<h4>Conclusion</h4>In conclusion, the results of our study support the hypothesis that longer exposure to effect of female sex hormones may increase the risk of meningioma in women, yet additional studies are warranted to confirm our findings and identify the underlying biological mechanisms.
format	article
author	Zhen-Yu Qi Chuan Shao Yu-Lun Huang Guo-Zhen Hui You-Xin Zhou Zhong Wang
author_facet	Zhen-Yu Qi Chuan Shao Yu-Lun Huang Guo-Zhen Hui You-Xin Zhou Zhong Wang
author_sort	Zhen-Yu Qi
title	Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.
title_short	Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.
title_full	Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.
title_fullStr	Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.
title_full_unstemmed	Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.
title_sort	reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d093ec7438e54402bdfb8b7614527aff
work_keys_str_mv	AT zhenyuqi reproductiveandexogenoushormonefactorsinrelationtoriskofmeningiomainwomenametaanalysis AT chuanshao reproductiveandexogenoushormonefactorsinrelationtoriskofmeningiomainwomenametaanalysis AT yulunhuang reproductiveandexogenoushormonefactorsinrelationtoriskofmeningiomainwomenametaanalysis AT guozhenhui reproductiveandexogenoushormonefactorsinrelationtoriskofmeningiomainwomenametaanalysis AT youxinzhou reproductiveandexogenoushormonefactorsinrelationtoriskofmeningiomainwomenametaanalysis AT zhongwang reproductiveandexogenoushormonefactorsinrelationtoriskofmeningiomainwomenametaanalysis
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Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.

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