CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes

Abstract Diabetic retinopathy (DR) is a major microvascular complication of diabetes. Susceptibility genes for type 2 diabetes may also impact the susceptibility of DR. This case-control study investigated the effects of 88 type 2 diabetes susceptibility loci on DR in a Chinese population with type...

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Autores principales:	Danfeng Peng, Jie Wang, Rong Zhang, Feng Jiang, Claudia H. T. Tam, Guozhi Jiang, Tao Wang, Miao Chen, Jing Yan, Shiyun Wang, Dandan Yan, Zhen He, Ronald C. W. Ma, Yuqian Bao, Cheng Hu, Weiping Jia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0956d1c461c4ec38f48d346bc0d4a44
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spelling	oai:doaj.org-article:d0956d1c461c4ec38f48d346bc0d4a442021-12-02T16:06:22ZCDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes10.1038/s41598-017-09010-w2045-2322https://doaj.org/article/d0956d1c461c4ec38f48d346bc0d4a442017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09010-whttps://doaj.org/toc/2045-2322Abstract Diabetic retinopathy (DR) is a major microvascular complication of diabetes. Susceptibility genes for type 2 diabetes may also impact the susceptibility of DR. This case-control study investigated the effects of 88 type 2 diabetes susceptibility loci on DR in a Chinese population with type 2 diabetes performed in two stages. In stage 1, 88 SNPs were genotyped in 1,251 patients with type 2 diabetes, and we found that ADAMTS9-AS2 rs4607103, WFS1 rs10010131, CDKAL1 rs7756992, VPS26A rs1802295 and IDE-KIF11-HHEX rs1111875 were significantly associated with DR. The association between CDKAL1 rs7756992 and DR remained significant after Bonferroni correction for multiple comparisons (corrected P = 0.0492). Then, the effect of rs7756992 on DR were analysed in two independent cohorts for replication in stage 2. Cohort (1) consisted of 380 patients with DR and 613 patients with diabetes for ≥5 years but without DR. Cohort (2) consisted of 545 patients with DR and 929 patients with diabetes for ≥5 years but without DR. A meta-analysis combining the results of stage 1 and 2 revealed a significant association between rs7756992 and DR, with the minor allele A conferring a lower risk of DR (OR 0.824, 95% CI 0.743–0.914, P = 2.46 × 10−4).Danfeng PengJie WangRong ZhangFeng JiangClaudia H. T. TamGuozhi JiangTao WangMiao ChenJing YanShiyun WangDandan YanZhen HeRonald C. W. MaYuqian BaoCheng HuWeiping JiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danfeng Peng Jie Wang Rong Zhang Feng Jiang Claudia H. T. Tam Guozhi Jiang Tao Wang Miao Chen Jing Yan Shiyun Wang Dandan Yan Zhen He Ronald C. W. Ma Yuqian Bao Cheng Hu Weiping Jia CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes
description	Abstract Diabetic retinopathy (DR) is a major microvascular complication of diabetes. Susceptibility genes for type 2 diabetes may also impact the susceptibility of DR. This case-control study investigated the effects of 88 type 2 diabetes susceptibility loci on DR in a Chinese population with type 2 diabetes performed in two stages. In stage 1, 88 SNPs were genotyped in 1,251 patients with type 2 diabetes, and we found that ADAMTS9-AS2 rs4607103, WFS1 rs10010131, CDKAL1 rs7756992, VPS26A rs1802295 and IDE-KIF11-HHEX rs1111875 were significantly associated with DR. The association between CDKAL1 rs7756992 and DR remained significant after Bonferroni correction for multiple comparisons (corrected P = 0.0492). Then, the effect of rs7756992 on DR were analysed in two independent cohorts for replication in stage 2. Cohort (1) consisted of 380 patients with DR and 613 patients with diabetes for ≥5 years but without DR. Cohort (2) consisted of 545 patients with DR and 929 patients with diabetes for ≥5 years but without DR. A meta-analysis combining the results of stage 1 and 2 revealed a significant association between rs7756992 and DR, with the minor allele A conferring a lower risk of DR (OR 0.824, 95% CI 0.743–0.914, P = 2.46 × 10−4).
format	article
author	Danfeng Peng Jie Wang Rong Zhang Feng Jiang Claudia H. T. Tam Guozhi Jiang Tao Wang Miao Chen Jing Yan Shiyun Wang Dandan Yan Zhen He Ronald C. W. Ma Yuqian Bao Cheng Hu Weiping Jia
author_facet	Danfeng Peng Jie Wang Rong Zhang Feng Jiang Claudia H. T. Tam Guozhi Jiang Tao Wang Miao Chen Jing Yan Shiyun Wang Dandan Yan Zhen He Ronald C. W. Ma Yuqian Bao Cheng Hu Weiping Jia
author_sort	Danfeng Peng
title	CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes
title_short	CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes
title_full	CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes
title_fullStr	CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes
title_full_unstemmed	CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes
title_sort	cdkal1 rs7756992 is associated with diabetic retinopathy in a chinese population with type 2 diabetes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d0956d1c461c4ec38f48d346bc0d4a44
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CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes

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