Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer

One of the major obstacles in nanoparticle-based therapy is to achieve tumour targeting, limiting non-specific accumulation of the nanoparticles. Here the authors propose the conjugation of anti-HER2 scFv fragments to the silica nanoparticles, increasing specificity and limiting the final size of th...

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Autores principales:	Feng Chen, Kai Ma, Brian Madajewski, Li Zhuang, Li Zhang, Keith Rickert, Marcello Marelli, Barney Yoo, Melik Z. Turker, Michael Overholtzer, Thomas P. Quinn, Mithat Gonen, Pat Zanzonico, Anthony Tuesca, Michael A. Bowen, Larry Norton, J. Anand Subramony, Ulrich Wiesner, Michelle S. Bradbury
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d095ee381fd844ee881d6637c08ac110
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spelling	oai:doaj.org-article:d095ee381fd844ee881d6637c08ac1102021-12-02T15:34:27ZUltrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer10.1038/s41467-018-06271-52041-1723https://doaj.org/article/d095ee381fd844ee881d6637c08ac1102018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06271-5https://doaj.org/toc/2041-1723One of the major obstacles in nanoparticle-based therapy is to achieve tumour targeting, limiting non-specific accumulation of the nanoparticles. Here the authors propose the conjugation of anti-HER2 scFv fragments to the silica nanoparticles, increasing specificity and limiting the final size of the immunoconjugates below the renal clearance threshold.Feng ChenKai MaBrian MadajewskiLi ZhuangLi ZhangKeith RickertMarcello MarelliBarney YooMelik Z. TurkerMichael OverholtzerThomas P. QuinnMithat GonenPat ZanzonicoAnthony TuescaMichael A. BowenLarry NortonJ. Anand SubramonyUlrich WiesnerMichelle S. BradburyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feng Chen Kai Ma Brian Madajewski Li Zhuang Li Zhang Keith Rickert Marcello Marelli Barney Yoo Melik Z. Turker Michael Overholtzer Thomas P. Quinn Mithat Gonen Pat Zanzonico Anthony Tuesca Michael A. Bowen Larry Norton J. Anand Subramony Ulrich Wiesner Michelle S. Bradbury Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
description	One of the major obstacles in nanoparticle-based therapy is to achieve tumour targeting, limiting non-specific accumulation of the nanoparticles. Here the authors propose the conjugation of anti-HER2 scFv fragments to the silica nanoparticles, increasing specificity and limiting the final size of the immunoconjugates below the renal clearance threshold.
format	article
author	Feng Chen Kai Ma Brian Madajewski Li Zhuang Li Zhang Keith Rickert Marcello Marelli Barney Yoo Melik Z. Turker Michael Overholtzer Thomas P. Quinn Mithat Gonen Pat Zanzonico Anthony Tuesca Michael A. Bowen Larry Norton J. Anand Subramony Ulrich Wiesner Michelle S. Bradbury
author_facet	Feng Chen Kai Ma Brian Madajewski Li Zhuang Li Zhang Keith Rickert Marcello Marelli Barney Yoo Melik Z. Turker Michael Overholtzer Thomas P. Quinn Mithat Gonen Pat Zanzonico Anthony Tuesca Michael A. Bowen Larry Norton J. Anand Subramony Ulrich Wiesner Michelle S. Bradbury
author_sort	Feng Chen
title	Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
title_short	Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
title_full	Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
title_fullStr	Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
title_full_unstemmed	Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
title_sort	ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of her2-overexpressing breast cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d095ee381fd844ee881d6637c08ac110
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Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer

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