Cadmium exposure and its association with serum uric acid and hyperuricemia

Abstract Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared to populations in other countries. To determine whether CdB in Chinese adults is a...

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Autores principales:	Honglin Sun, Ningjian Wang, Chi Chen, Xiaomin Nie, Bing Han, Qin Li, Chunfang Zhu, Yi Chen, Fangzhen Xia, Yingchao Chen, Hualing Zhai, Boren Jiang, Bin Hu, Yingli Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d09d7451b71c4b50bc70052933a73dbb
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spelling	oai:doaj.org-article:d09d7451b71c4b50bc70052933a73dbb2021-12-02T15:06:08ZCadmium exposure and its association with serum uric acid and hyperuricemia10.1038/s41598-017-00661-32045-2322https://doaj.org/article/d09d7451b71c4b50bc70052933a73dbb2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00661-3https://doaj.org/toc/2045-2322Abstract Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared to populations in other countries. To determine whether CdB in Chinese adults is associated with serum UA and hyperuricemia, 2996 participants from the cross-sectional SPECT-China study were recruited. CdB was measured by atomic absorption spectrometry. Hyperuricemia was defined as a serum UA concentration ≥416.4 μmol/L for men and ≥356.9 μmol/L for women. Regression analyses were used to analyze the association of CdB with serum UA and hyperuricemia. We found that the median CdB level was higher in men with hyperuricemia (2.40 μg/L) than in men without hyperuricemia (1.98 μg/L, P < 0.05). A positive relationship between serum UA and CdB was found in Chinese men after adjusting for the estimated glomerular filtration rate (eGFR), current smoking status, diabetes, dyslipidemia, hypertension and body mass index and in participants with eGFR > 60 mL/min per 1.73 m2. Further, the odds ratio of hyperuricemia increased with increasing CdB quartiles (P for trend < 0.05) in men. In conclusion, CdB was positively related to the serum UA level and to hyperuricemia in Chinese men but not in Chinese women.Honglin SunNingjian WangChi ChenXiaomin NieBing HanQin LiChunfang ZhuYi ChenFangzhen XiaYingchao ChenHualing ZhaiBoren JiangBin HuYingli LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Honglin Sun Ningjian Wang Chi Chen Xiaomin Nie Bing Han Qin Li Chunfang Zhu Yi Chen Fangzhen Xia Yingchao Chen Hualing Zhai Boren Jiang Bin Hu Yingli Lu Cadmium exposure and its association with serum uric acid and hyperuricemia
description	Abstract Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared to populations in other countries. To determine whether CdB in Chinese adults is associated with serum UA and hyperuricemia, 2996 participants from the cross-sectional SPECT-China study were recruited. CdB was measured by atomic absorption spectrometry. Hyperuricemia was defined as a serum UA concentration ≥416.4 μmol/L for men and ≥356.9 μmol/L for women. Regression analyses were used to analyze the association of CdB with serum UA and hyperuricemia. We found that the median CdB level was higher in men with hyperuricemia (2.40 μg/L) than in men without hyperuricemia (1.98 μg/L, P < 0.05). A positive relationship between serum UA and CdB was found in Chinese men after adjusting for the estimated glomerular filtration rate (eGFR), current smoking status, diabetes, dyslipidemia, hypertension and body mass index and in participants with eGFR > 60 mL/min per 1.73 m2. Further, the odds ratio of hyperuricemia increased with increasing CdB quartiles (P for trend < 0.05) in men. In conclusion, CdB was positively related to the serum UA level and to hyperuricemia in Chinese men but not in Chinese women.
format	article
author	Honglin Sun Ningjian Wang Chi Chen Xiaomin Nie Bing Han Qin Li Chunfang Zhu Yi Chen Fangzhen Xia Yingchao Chen Hualing Zhai Boren Jiang Bin Hu Yingli Lu
author_facet	Honglin Sun Ningjian Wang Chi Chen Xiaomin Nie Bing Han Qin Li Chunfang Zhu Yi Chen Fangzhen Xia Yingchao Chen Hualing Zhai Boren Jiang Bin Hu Yingli Lu
author_sort	Honglin Sun
title	Cadmium exposure and its association with serum uric acid and hyperuricemia
title_short	Cadmium exposure and its association with serum uric acid and hyperuricemia
title_full	Cadmium exposure and its association with serum uric acid and hyperuricemia
title_fullStr	Cadmium exposure and its association with serum uric acid and hyperuricemia
title_full_unstemmed	Cadmium exposure and its association with serum uric acid and hyperuricemia
title_sort	cadmium exposure and its association with serum uric acid and hyperuricemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d09d7451b71c4b50bc70052933a73dbb
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Cadmium exposure and its association with serum uric acid and hyperuricemia

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