Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas

Papillary thyroid cancer (PTC) is one of the most common type of endocrine malignancy. Here, the authors use proteogenomic approaches to analyse the primary tumour and lymph node metastases from a PTC patient and report an oncogenic RET fusion, and potential druggable targets from the ubiquitin sign...

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Autores principales:	Aswini Krishnan, Jean Berthelet, Emilie Renaud, Sebastian Rosigkeit, Ute Distler, Eric Stawiski, Jing Wang, Zora Modrusan, Marc Fiedler, Mariann Bienz, Stefan Tenzer, Arno Schad, Wilfried Roth, Bernd Thiede, Somasekar Seshagiri, Thomas J. Musholt, Krishnaraj Rajalingam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0a0473fc75243f2b229229426d6900d
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spelling	oai:doaj.org-article:d0a0473fc75243f2b229229426d6900d2021-12-02T15:37:20ZProteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas10.1038/s41467-020-15955-w2041-1723https://doaj.org/article/d0a0473fc75243f2b229229426d6900d2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15955-whttps://doaj.org/toc/2041-1723Papillary thyroid cancer (PTC) is one of the most common type of endocrine malignancy. Here, the authors use proteogenomic approaches to analyse the primary tumour and lymph node metastases from a PTC patient and report an oncogenic RET fusion, and potential druggable targets from the ubiquitin signaling machinery for treating human PTCs.Aswini KrishnanJean BertheletEmilie RenaudSebastian RosigkeitUte DistlerEric StawiskiJing WangZora ModrusanMarc FiedlerMariann BienzStefan TenzerArno SchadWilfried RothBernd ThiedeSomasekar SeshagiriThomas J. MusholtKrishnaraj RajalingamNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aswini Krishnan Jean Berthelet Emilie Renaud Sebastian Rosigkeit Ute Distler Eric Stawiski Jing Wang Zora Modrusan Marc Fiedler Mariann Bienz Stefan Tenzer Arno Schad Wilfried Roth Bernd Thiede Somasekar Seshagiri Thomas J. Musholt Krishnaraj Rajalingam Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
description	Papillary thyroid cancer (PTC) is one of the most common type of endocrine malignancy. Here, the authors use proteogenomic approaches to analyse the primary tumour and lymph node metastases from a PTC patient and report an oncogenic RET fusion, and potential druggable targets from the ubiquitin signaling machinery for treating human PTCs.
format	article
author	Aswini Krishnan Jean Berthelet Emilie Renaud Sebastian Rosigkeit Ute Distler Eric Stawiski Jing Wang Zora Modrusan Marc Fiedler Mariann Bienz Stefan Tenzer Arno Schad Wilfried Roth Bernd Thiede Somasekar Seshagiri Thomas J. Musholt Krishnaraj Rajalingam
author_facet	Aswini Krishnan Jean Berthelet Emilie Renaud Sebastian Rosigkeit Ute Distler Eric Stawiski Jing Wang Zora Modrusan Marc Fiedler Mariann Bienz Stefan Tenzer Arno Schad Wilfried Roth Bernd Thiede Somasekar Seshagiri Thomas J. Musholt Krishnaraj Rajalingam
author_sort	Aswini Krishnan
title	Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
title_short	Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
title_full	Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
title_fullStr	Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
title_full_unstemmed	Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
title_sort	proteogenomics analysis unveils a tfg-ret gene fusion and druggable targets in papillary thyroid carcinomas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d0a0473fc75243f2b229229426d6900d
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Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas

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