The Modular Organization of Protein Interactions in Escherichia coli.

Escherichia coli serves as an excellent model for the study of fundamental cellular processes such as metabolism, signalling and gene expression. Understanding the function and organization of proteins within these processes is an important step towards a 'systems' view of E. coli. Integra...

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Autores principales:	José M Peregrín-Alvarez, Xuejian Xiong, Chong Su, John Parkinson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d0a5e25c3bd14798bf2065ee7ea09b18
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spelling	oai:doaj.org-article:d0a5e25c3bd14798bf2065ee7ea09b182021-11-25T05:42:08ZThe Modular Organization of Protein Interactions in Escherichia coli.1553-734X1553-735810.1371/journal.pcbi.1000523https://doaj.org/article/d0a5e25c3bd14798bf2065ee7ea09b182009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19798435/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Escherichia coli serves as an excellent model for the study of fundamental cellular processes such as metabolism, signalling and gene expression. Understanding the function and organization of proteins within these processes is an important step towards a 'systems' view of E. coli. Integrating experimental and computational interaction data, we present a reliable network of 3,989 functional interactions between 1,941 E. coli proteins ( approximately 45% of its proteome). These were combined with a recently generated set of 3,888 high-quality physical interactions between 918 proteins and clustered to reveal 316 discrete modules. In addition to known protein complexes (e.g., RNA and DNA polymerases), we identified modules that represent biochemical pathways (e.g., nitrate regulation and cell wall biosynthesis) as well as batteries of functionally and evolutionarily related processes. To aid the interpretation of modular relationships, several case examples are presented, including both well characterized and novel biochemical systems. Together these data provide a global view of the modular organization of the E. coli proteome and yield unique insights into structural and evolutionary relationships in bacterial networks.José M Peregrín-AlvarezXuejian XiongChong SuJohn ParkinsonPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 5, Iss 10, p e1000523 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 José M Peregrín-Alvarez Xuejian Xiong Chong Su John Parkinson The Modular Organization of Protein Interactions in Escherichia coli.
description	Escherichia coli serves as an excellent model for the study of fundamental cellular processes such as metabolism, signalling and gene expression. Understanding the function and organization of proteins within these processes is an important step towards a 'systems' view of E. coli. Integrating experimental and computational interaction data, we present a reliable network of 3,989 functional interactions between 1,941 E. coli proteins ( approximately 45% of its proteome). These were combined with a recently generated set of 3,888 high-quality physical interactions between 918 proteins and clustered to reveal 316 discrete modules. In addition to known protein complexes (e.g., RNA and DNA polymerases), we identified modules that represent biochemical pathways (e.g., nitrate regulation and cell wall biosynthesis) as well as batteries of functionally and evolutionarily related processes. To aid the interpretation of modular relationships, several case examples are presented, including both well characterized and novel biochemical systems. Together these data provide a global view of the modular organization of the E. coli proteome and yield unique insights into structural and evolutionary relationships in bacterial networks.
format	article
author	José M Peregrín-Alvarez Xuejian Xiong Chong Su John Parkinson
author_facet	José M Peregrín-Alvarez Xuejian Xiong Chong Su John Parkinson
author_sort	José M Peregrín-Alvarez
title	The Modular Organization of Protein Interactions in Escherichia coli.
title_short	The Modular Organization of Protein Interactions in Escherichia coli.
title_full	The Modular Organization of Protein Interactions in Escherichia coli.
title_fullStr	The Modular Organization of Protein Interactions in Escherichia coli.
title_full_unstemmed	The Modular Organization of Protein Interactions in Escherichia coli.
title_sort	modular organization of protein interactions in escherichia coli.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/d0a5e25c3bd14798bf2065ee7ea09b18
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_version_	1718414546237915136

The Modular Organization of Protein Interactions in Escherichia coli.

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