Age-related macular degeneration and the aging eye

Rita Ehrlich1, Alon Harris1, Nisha S Kheradiya1, Diana M Winston1, Thomas A Ciulla3, Barbara Wirostko21Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA; 2Stony Brook University Medical Center Research Way, Department of Ophthalmology, Stony Brook, NY, USA; 3R...

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Autores principales:	Rita Ehrlich, Alon Harris, Nisha S Kheradiya, Diana M Winston, Thomas A Ciulla, Barbara Wirostko
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d0ab76c20e074755b0639536ea85d93a
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spelling	oai:doaj.org-article:d0ab76c20e074755b0639536ea85d93a2021-12-02T06:48:49ZAge-related macular degeneration and the aging eye1178-1998https://doaj.org/article/d0ab76c20e074755b0639536ea85d93a2008-09-01T00:00:00Zhttps://www.dovepress.com/age-related-macular-degeneration-and-the-aging-eye-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Rita Ehrlich1, Alon Harris1, Nisha S Kheradiya1, Diana M Winston1, Thomas A Ciulla3, Barbara Wirostko21Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA; 2Stony Brook University Medical Center Research Way, Department of Ophthalmology, Stony Brook, NY, USA; 3Retina Service, Midwest Eye Institute, Attending Physician and Surgeon, Methodist Hospital, Indianapolis, IN, USAAbstract: Age-related macular degeneration (AMD) is an ocular disease that causes damage to the retinal macula, mostly in the elderly. Normal aging processes can lead to structural and blood flow changes that can predispose patients to AMD, although advanced age does not inevitably cause AMD. In this review, we describe changes that occur in the macular structure, such as the retinal pigment epithelium and Bruch’s membrane, with advancing age and in AMD. The role of genetics in AMD and age-related changes in ocular blood flow that may play a role in the pathogenesis of AMD are also discussed. Understanding the pathophysiology of AMD development can help guide future research to further comprehend this disease and to develop better treatments to prevent its irreversible central vision loss in the elderly.Keywords: age-related macular degeneration, aging, blood flow, eye, retina, macula, visionRita EhrlichAlon HarrisNisha S KheradiyaDiana M WinstonThomas A CiullaBarbara WirostkoDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 473-482 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Rita Ehrlich Alon Harris Nisha S Kheradiya Diana M Winston Thomas A Ciulla Barbara Wirostko Age-related macular degeneration and the aging eye
description	Rita Ehrlich1, Alon Harris1, Nisha S Kheradiya1, Diana M Winston1, Thomas A Ciulla3, Barbara Wirostko21Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA; 2Stony Brook University Medical Center Research Way, Department of Ophthalmology, Stony Brook, NY, USA; 3Retina Service, Midwest Eye Institute, Attending Physician and Surgeon, Methodist Hospital, Indianapolis, IN, USAAbstract: Age-related macular degeneration (AMD) is an ocular disease that causes damage to the retinal macula, mostly in the elderly. Normal aging processes can lead to structural and blood flow changes that can predispose patients to AMD, although advanced age does not inevitably cause AMD. In this review, we describe changes that occur in the macular structure, such as the retinal pigment epithelium and Bruch’s membrane, with advancing age and in AMD. The role of genetics in AMD and age-related changes in ocular blood flow that may play a role in the pathogenesis of AMD are also discussed. Understanding the pathophysiology of AMD development can help guide future research to further comprehend this disease and to develop better treatments to prevent its irreversible central vision loss in the elderly.Keywords: age-related macular degeneration, aging, blood flow, eye, retina, macula, vision
format	article
author	Rita Ehrlich Alon Harris Nisha S Kheradiya Diana M Winston Thomas A Ciulla Barbara Wirostko
author_facet	Rita Ehrlich Alon Harris Nisha S Kheradiya Diana M Winston Thomas A Ciulla Barbara Wirostko
author_sort	Rita Ehrlich
title	Age-related macular degeneration and the aging eye
title_short	Age-related macular degeneration and the aging eye
title_full	Age-related macular degeneration and the aging eye
title_fullStr	Age-related macular degeneration and the aging eye
title_full_unstemmed	Age-related macular degeneration and the aging eye
title_sort	age-related macular degeneration and the aging eye
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/d0ab76c20e074755b0639536ea85d93a
work_keys_str_mv	AT ritaehrlich agerelatedmaculardegenerationandtheagingeye AT alonharris agerelatedmaculardegenerationandtheagingeye AT nishaskheradiya agerelatedmaculardegenerationandtheagingeye AT dianamwinston agerelatedmaculardegenerationandtheagingeye AT thomasaciulla agerelatedmaculardegenerationandtheagingeye AT barbarawirostko agerelatedmaculardegenerationandtheagingeye
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Age-related macular degeneration and the aging eye

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