Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes

Background: Microwave radiometry (MWR) assesses non-invasive carotid artery temperatures reflecting inflammation. In the present study, we aimed to investigate the impact of hypolipidemic therapy either with simvastatin or with combination simvastatin plus ezetimibe on carotid artery temperatures of...

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Autores principales:	Georgios Benetos, Spyros Galanakos, Iosif Koutagiar, Ioannis Skoumas, Georgios Oikonomou, Maria Drakopoulou, Maria Karmpalioti, Vasiliki Katsi, Costas Tsioufis, Konstantinos Toutouzas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microwave radiometry carotid vulnerable plaque familial hypercholesterolemia Medicine R
Acceso en línea:	https://doaj.org/article/d0ac3fd61dc148489eb26aa9ec5b93b8
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spelling	oai:doaj.org-article:d0ac3fd61dc148489eb26aa9ec5b93b82021-11-11T17:38:19ZCarotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes10.3390/jcm102150082077-0383https://doaj.org/article/d0ac3fd61dc148489eb26aa9ec5b93b82021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5008https://doaj.org/toc/2077-0383Background: Microwave radiometry (MWR) assesses non-invasive carotid artery temperatures reflecting inflammation. In the present study, we aimed to investigate the impact of hypolipidemic therapy either with simvastatin or with combination simvastatin plus ezetimibe on carotid artery temperatures of patients with familial hyperlipidemia syndromes (FHS). Methods: Consecutive patients with diagnosis of either familial heterozygous hypercholesterolemia (heFH) or familial combined hyperlipidemia (FCH) were included in the study. Patients were assigned to either simvastatin 40 mg or simvastatin 40 mg plus ezetimibe 10 mg, according to the discretion of the physician. FHS patients who refused statin therapy were used as a control group. Common carotid intima-media thickness (ccIMT) was measured and ΔΤ (maximum-minimum) temperature measurements were performed across each carotid during MWR evaluation. RESULTS: In total, 115 patients were included in the study. Of them, 40 patients received simvastatin (19 heFH and 21 FCH), 41 simvastatin + ezetimibe (31 heFH and 10 FCH), and 34 (21 heFH and 13 FCH) no statin. Carotid artery temperatures were significantly reduced at 6 months in FH patients who received hypolipidemic treatment (0.83 ± 0.34 versus 0.63 ± 0.24 °C, <i>p</i> = 0.004 for simvastatin, 1.00 ± 0.38 versus 0.69 ± 0.23 °C, <i>p</i> < 0.001 for simvastatin + ezetimibe), but no change was recorded in controls (0.72 ± 0.26 versus 0.70 ± 0.26 °C, <i>p</i> = 0.86). Conclusions: Hypolipidemic therapy reduced carotid temperatures in FHS patients.Georgios BenetosSpyros GalanakosIosif KoutagiarIoannis SkoumasGeorgios OikonomouMaria DrakopoulouMaria KarmpaliotiVasiliki KatsiCostas TsioufisKonstantinos ToutouzasMDPI AGarticlemicrowave radiometrycarotidvulnerable plaquefamilial hypercholesterolemiaMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5008, p 5008 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microwave radiometry carotid vulnerable plaque familial hypercholesterolemia Medicine R
spellingShingle	microwave radiometry carotid vulnerable plaque familial hypercholesterolemia Medicine R Georgios Benetos Spyros Galanakos Iosif Koutagiar Ioannis Skoumas Georgios Oikonomou Maria Drakopoulou Maria Karmpalioti Vasiliki Katsi Costas Tsioufis Konstantinos Toutouzas Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
description	Background: Microwave radiometry (MWR) assesses non-invasive carotid artery temperatures reflecting inflammation. In the present study, we aimed to investigate the impact of hypolipidemic therapy either with simvastatin or with combination simvastatin plus ezetimibe on carotid artery temperatures of patients with familial hyperlipidemia syndromes (FHS). Methods: Consecutive patients with diagnosis of either familial heterozygous hypercholesterolemia (heFH) or familial combined hyperlipidemia (FCH) were included in the study. Patients were assigned to either simvastatin 40 mg or simvastatin 40 mg plus ezetimibe 10 mg, according to the discretion of the physician. FHS patients who refused statin therapy were used as a control group. Common carotid intima-media thickness (ccIMT) was measured and ΔΤ (maximum-minimum) temperature measurements were performed across each carotid during MWR evaluation. RESULTS: In total, 115 patients were included in the study. Of them, 40 patients received simvastatin (19 heFH and 21 FCH), 41 simvastatin + ezetimibe (31 heFH and 10 FCH), and 34 (21 heFH and 13 FCH) no statin. Carotid artery temperatures were significantly reduced at 6 months in FH patients who received hypolipidemic treatment (0.83 ± 0.34 versus 0.63 ± 0.24 °C, <i>p</i> = 0.004 for simvastatin, 1.00 ± 0.38 versus 0.69 ± 0.23 °C, <i>p</i> < 0.001 for simvastatin + ezetimibe), but no change was recorded in controls (0.72 ± 0.26 versus 0.70 ± 0.26 °C, <i>p</i> = 0.86). Conclusions: Hypolipidemic therapy reduced carotid temperatures in FHS patients.
format	article
author	Georgios Benetos Spyros Galanakos Iosif Koutagiar Ioannis Skoumas Georgios Oikonomou Maria Drakopoulou Maria Karmpalioti Vasiliki Katsi Costas Tsioufis Konstantinos Toutouzas
author_facet	Georgios Benetos Spyros Galanakos Iosif Koutagiar Ioannis Skoumas Georgios Oikonomou Maria Drakopoulou Maria Karmpalioti Vasiliki Katsi Costas Tsioufis Konstantinos Toutouzas
author_sort	Georgios Benetos
title	Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_short	Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_full	Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_fullStr	Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_full_unstemmed	Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes
title_sort	carotid artery temperature reduction with statin therapy in patients with familial hyperlipidemia syndromes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d0ac3fd61dc148489eb26aa9ec5b93b8
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Carotid Artery Temperature Reduction with Statin Therapy in Patients with Familial Hyperlipidemia Syndromes

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