Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease

Abstract The objective of this study was to determine biological effects of Cirsium japonicum extract and its main component cirsimaritin on high‐fat diet (HFD)‐induced metabolic dysfunction‐associated fatty liver disease (MAFLD) in a mouse model. Mice were fed with a HFD to induce MAFLD and simulta...

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Autores principales:	Denis Nchang Che, Jae Young Shin, Hyun Ju Kang, Byoung Ok Cho, Ji Hyeon Park, Feng Wang, Suping Hao, Jae Suk Sim, Dong Jun Sim, Seon Il Jang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Cirsimaritin Cirsium japonicum fatty liver inflammation MAFLD oxidative stress Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/d0add3641fa1478ab0d044fea913d648
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spelling	oai:doaj.org-article:d0add3641fa1478ab0d044fea913d6482021-11-04T13:06:43ZAmeliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease2048-717710.1002/fsn3.2548https://doaj.org/article/d0add3641fa1478ab0d044fea913d6482021-11-01T00:00:00Zhttps://doi.org/10.1002/fsn3.2548https://doaj.org/toc/2048-7177Abstract The objective of this study was to determine biological effects of Cirsium japonicum extract and its main component cirsimaritin on high‐fat diet (HFD)‐induced metabolic dysfunction‐associated fatty liver disease (MAFLD) in a mouse model. Mice were fed with a HFD to induce MAFLD and simultaneously administered with C. japonicum extract (CJE) or cirsimaritin. Various MAFLD biomarkers were evaluated using biological methods. Results demonstrated that triglyceride, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels in the liver of mice were significantly reduced upon administration of CJE or cirsimaritin. Treatment with CJE or cirsimaritin also reduced the severity of liver injury in the experimental mouse model of MAFLD by inhibiting hepatic steatosis, oxidative stress, inflammation, and liver fibrosis. These results demonstrate that CJE and cirsimaritin as its main compound have a preventive action against the progression of hepatic steatosis to fibrosis and cirrhosis. Our study suggests that CJE and cirsimaritin might be promising agents for preventing and/or treating MAFLD.Denis Nchang CheJae Young ShinHyun Ju KangByoung Ok ChoJi Hyeon ParkFeng WangSuping HaoJae Suk SimDong Jun SimSeon Il JangWileyarticleCirsimaritinCirsium japonicumfatty liverinflammationMAFLDoxidative stressNutrition. Foods and food supplyTX341-641ENFood Science & Nutrition, Vol 9, Iss 11, Pp 6060-6068 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cirsimaritin Cirsium japonicum fatty liver inflammation MAFLD oxidative stress Nutrition. Foods and food supply TX341-641
spellingShingle	Cirsimaritin Cirsium japonicum fatty liver inflammation MAFLD oxidative stress Nutrition. Foods and food supply TX341-641 Denis Nchang Che Jae Young Shin Hyun Ju Kang Byoung Ok Cho Ji Hyeon Park Feng Wang Suping Hao Jae Suk Sim Dong Jun Sim Seon Il Jang Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease
description	Abstract The objective of this study was to determine biological effects of Cirsium japonicum extract and its main component cirsimaritin on high‐fat diet (HFD)‐induced metabolic dysfunction‐associated fatty liver disease (MAFLD) in a mouse model. Mice were fed with a HFD to induce MAFLD and simultaneously administered with C. japonicum extract (CJE) or cirsimaritin. Various MAFLD biomarkers were evaluated using biological methods. Results demonstrated that triglyceride, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels in the liver of mice were significantly reduced upon administration of CJE or cirsimaritin. Treatment with CJE or cirsimaritin also reduced the severity of liver injury in the experimental mouse model of MAFLD by inhibiting hepatic steatosis, oxidative stress, inflammation, and liver fibrosis. These results demonstrate that CJE and cirsimaritin as its main compound have a preventive action against the progression of hepatic steatosis to fibrosis and cirrhosis. Our study suggests that CJE and cirsimaritin might be promising agents for preventing and/or treating MAFLD.
format	article
author	Denis Nchang Che Jae Young Shin Hyun Ju Kang Byoung Ok Cho Ji Hyeon Park Feng Wang Suping Hao Jae Suk Sim Dong Jun Sim Seon Il Jang
author_facet	Denis Nchang Che Jae Young Shin Hyun Ju Kang Byoung Ok Cho Ji Hyeon Park Feng Wang Suping Hao Jae Suk Sim Dong Jun Sim Seon Il Jang
author_sort	Denis Nchang Che
title	Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease
title_short	Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease
title_full	Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease
title_fullStr	Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease
title_full_unstemmed	Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease
title_sort	ameliorative effects of cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/d0add3641fa1478ab0d044fea913d648
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Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high‐fat diet‐induced metabolic dysfunction‐associated fatty liver disease

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