Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects against steatohepatitis in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Arthur C. Sletten, Jessica W. Davidson, Busra Yagabasan, Samantha Moores, Michaela Schwaiger-Haber, Hideji Fujiwara, Sarah Gale, Xuntian Jiang, Rohini Sidhu, Susan Gelman, Shuang Zhao, Gary Patti, Daniel S. Ory, Jean E. Schaffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0b59c5a040d41be8c7d87c9047d2474
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d0b59c5a040d41be8c7d87c9047d2474
record_format	dspace
spelling	oai:doaj.org-article:d0b59c5a040d41be8c7d87c9047d24742021-12-02T16:37:39ZLoss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis10.1038/s41467-021-25457-y2041-1723https://doaj.org/article/d0b59c5a040d41be8c7d87c9047d24742021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25457-yhttps://doaj.org/toc/2041-1723Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects against steatohepatitis in mice.Arthur C. SlettenJessica W. DavidsonBusra YagabasanSamantha MooresMichaela Schwaiger-HaberHideji FujiwaraSarah GaleXuntian JiangRohini SidhuSusan GelmanShuang ZhaoGary PattiDaniel S. OryJean E. SchafferNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arthur C. Sletten Jessica W. Davidson Busra Yagabasan Samantha Moores Michaela Schwaiger-Haber Hideji Fujiwara Sarah Gale Xuntian Jiang Rohini Sidhu Susan Gelman Shuang Zhao Gary Patti Daniel S. Ory Jean E. Schaffer Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis
description	Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects against steatohepatitis in mice.
format	article
author	Arthur C. Sletten Jessica W. Davidson Busra Yagabasan Samantha Moores Michaela Schwaiger-Haber Hideji Fujiwara Sarah Gale Xuntian Jiang Rohini Sidhu Susan Gelman Shuang Zhao Gary Patti Daniel S. Ory Jean E. Schaffer
author_facet	Arthur C. Sletten Jessica W. Davidson Busra Yagabasan Samantha Moores Michaela Schwaiger-Haber Hideji Fujiwara Sarah Gale Xuntian Jiang Rohini Sidhu Susan Gelman Shuang Zhao Gary Patti Daniel S. Ory Jean E. Schaffer
author_sort	Arthur C. Sletten
title	Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis
title_short	Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis
title_full	Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis
title_fullStr	Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis
title_full_unstemmed	Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis
title_sort	loss of snora73 reprograms cellular metabolism and protects against steatohepatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d0b59c5a040d41be8c7d87c9047d2474
work_keys_str_mv	AT arthurcsletten lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT jessicawdavidson lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT busrayagabasan lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT samanthamoores lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT michaelaschwaigerhaber lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT hidejifujiwara lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT sarahgale lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT xuntianjiang lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT rohinisidhu lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT susangelman lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT shuangzhao lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT garypatti lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT danielsory lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis AT jeaneschaffer lossofsnora73reprogramscellularmetabolismandprotectsagainststeatohepatitis
_version_	1718383660164448256

Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

Ejemplares similares