Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects against steatohepatitis in mice.

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Auteurs principaux: Arthur C. Sletten, Jessica W. Davidson, Busra Yagabasan, Samantha Moores, Michaela Schwaiger-Haber, Hideji Fujiwara, Sarah Gale, Xuntian Jiang, Rohini Sidhu, Susan Gelman, Shuang Zhao, Gary Patti, Daniel S. Ory, Jean E. Schaffer
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/d0b59c5a040d41be8c7d87c9047d2474
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https://doaj.org/article/d0b59c5a040d41be8c7d87c9047d2474

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