Emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias

Xavier ThomasHospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service d&#39;H&eacute;matologie Clinique, Pavillon Marcel B&eacute;rard, B&acirc;t.1G, Pierre B&eacute;nite, FranceAbstract: The choice of treatment approach in acute leukemia depends on well-...

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Autor principal:	Thomas X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/d0b70b508c4540e7b81c16a8c5f8216b
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spelling	oai:doaj.org-article:d0b70b508c4540e7b81c16a8c5f8216b2021-12-02T05:28:23ZEmerging treatment approaches in acute lymphoblastic and acute myeloid leukemias1179-9889https://doaj.org/article/d0b70b508c4540e7b81c16a8c5f8216b2012-03-01T00:00:00Zhttp://www.dovepress.com/emerging-treatment-approaches-in-acute-lymphoblastic-and-acute-myeloid-a9406https://doaj.org/toc/1179-9889Xavier ThomasHospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service d&#39;H&eacute;matologie Clinique, Pavillon Marcel B&eacute;rard, B&acirc;t.1G, Pierre B&eacute;nite, FranceAbstract: The choice of treatment approach in acute leukemia depends on well-established prognostic factors. A number of features can predict the outcome of treatment including cytogenetics and an increasing list of molecular features. These are increasingly being used to direct postinduction therapy and support risk-adapted treatments that should achieve optimal results while minimizing nonrelapse mortality. In addition, they are also molecular targets for a new generation of small molecule inhibitors that are in early development and promise to further improve outcomes in the coming decade.Keywords: acute myeloid leukemia, acute lymphoblastic leukemia, treatment, targeted therapyThomas XDove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2012, Iss default, Pp 57-76 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Thomas X Emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias
description	Xavier ThomasHospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service d&#39;H&eacute;matologie Clinique, Pavillon Marcel B&eacute;rard, B&acirc;t.1G, Pierre B&eacute;nite, FranceAbstract: The choice of treatment approach in acute leukemia depends on well-established prognostic factors. A number of features can predict the outcome of treatment including cytogenetics and an increasing list of molecular features. These are increasingly being used to direct postinduction therapy and support risk-adapted treatments that should achieve optimal results while minimizing nonrelapse mortality. In addition, they are also molecular targets for a new generation of small molecule inhibitors that are in early development and promise to further improve outcomes in the coming decade.Keywords: acute myeloid leukemia, acute lymphoblastic leukemia, treatment, targeted therapy
format	article
author	Thomas X
author_facet	Thomas X
author_sort	Thomas X
title	Emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias
title_short	Emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias
title_full	Emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias
title_fullStr	Emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias
title_full_unstemmed	Emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias
title_sort	emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/d0b70b508c4540e7b81c16a8c5f8216b
work_keys_str_mv	AT thomasx emergingtreatmentapproachesinacutelymphoblasticandacutemyeloidleukemias
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Emerging treatment approaches in acute lymphoblastic and acute myeloid leukemias

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