Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

The phosphatidylinositol-3-phosphate (PI3P) is generated by the lipid kinase VPS34, in the context of VPS34 complex I on autophagosomes or complex II on endosomes. Biochemical and structural analyses provide insights into the mechanism of both VPS34 complexes recruitment to and activation on membran...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shirley Tremel, Yohei Ohashi, Dustin R. Morado, Jessie Bertram, Olga Perisic, Laura T. L. Brandt, Marie-Kristin von Wrisberg, Zhuo A. Chen, Sarah L. Maslen, Oleksiy Kovtun, Mark Skehel, Juri Rappsilber, Kathrin Lang, Sean Munro, John A. G. Briggs, Roger L. Williams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0b77c3d6f3f4cfcbbaf6326c8d008f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d0b77c3d6f3f4cfcbbaf6326c8d008f3
record_format	dspace
spelling	oai:doaj.org-article:d0b77c3d6f3f4cfcbbaf6326c8d008f32021-12-02T15:52:44ZStructural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes10.1038/s41467-021-21695-22041-1723https://doaj.org/article/d0b77c3d6f3f4cfcbbaf6326c8d008f32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21695-2https://doaj.org/toc/2041-1723The phosphatidylinositol-3-phosphate (PI3P) is generated by the lipid kinase VPS34, in the context of VPS34 complex I on autophagosomes or complex II on endosomes. Biochemical and structural analyses provide insights into the mechanism of both VPS34 complexes recruitment to and activation on membranes by specific Rab GTPases.Shirley TremelYohei OhashiDustin R. MoradoJessie BertramOlga PerisicLaura T. L. BrandtMarie-Kristin von WrisbergZhuo A. ChenSarah L. MaslenOleksiy KovtunMark SkehelJuri RappsilberKathrin LangSean MunroJohn A. G. BriggsRoger L. WilliamsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shirley Tremel Yohei Ohashi Dustin R. Morado Jessie Bertram Olga Perisic Laura T. L. Brandt Marie-Kristin von Wrisberg Zhuo A. Chen Sarah L. Maslen Oleksiy Kovtun Mark Skehel Juri Rappsilber Kathrin Lang Sean Munro John A. G. Briggs Roger L. Williams Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
description	The phosphatidylinositol-3-phosphate (PI3P) is generated by the lipid kinase VPS34, in the context of VPS34 complex I on autophagosomes or complex II on endosomes. Biochemical and structural analyses provide insights into the mechanism of both VPS34 complexes recruitment to and activation on membranes by specific Rab GTPases.
format	article
author	Shirley Tremel Yohei Ohashi Dustin R. Morado Jessie Bertram Olga Perisic Laura T. L. Brandt Marie-Kristin von Wrisberg Zhuo A. Chen Sarah L. Maslen Oleksiy Kovtun Mark Skehel Juri Rappsilber Kathrin Lang Sean Munro John A. G. Briggs Roger L. Williams
author_facet	Shirley Tremel Yohei Ohashi Dustin R. Morado Jessie Bertram Olga Perisic Laura T. L. Brandt Marie-Kristin von Wrisberg Zhuo A. Chen Sarah L. Maslen Oleksiy Kovtun Mark Skehel Juri Rappsilber Kathrin Lang Sean Munro John A. G. Briggs Roger L. Williams
author_sort	Shirley Tremel
title	Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
title_short	Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
title_full	Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
title_fullStr	Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
title_full_unstemmed	Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
title_sort	structural basis for vps34 kinase activation by rab1 and rab5 on membranes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d0b77c3d6f3f4cfcbbaf6326c8d008f3
work_keys_str_mv	AT shirleytremel structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT yoheiohashi structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT dustinrmorado structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT jessiebertram structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT olgaperisic structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT lauratlbrandt structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT mariekristinvonwrisberg structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT zhuoachen structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT sarahlmaslen structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT oleksiykovtun structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT markskehel structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT jurirappsilber structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT kathrinlang structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT seanmunro structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT johnagbriggs structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes AT rogerlwilliams structuralbasisforvps34kinaseactivationbyrab1andrab5onmembranes
_version_	1718385597938139136

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

Ejemplares similares