Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains

Abstract Seasonal influenza vaccine formulas change almost every year yet information about how this affects the antibody repertoire of vaccine recipients is inadequate. New vaccine virus strains are selected, replacing older strains to better match the currently circulating strains. But even while...

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Autores principales:	Ewan P. Plant, Lucy J. Fredell, Blake A. Hatcher, Xing Li, Meng-Jung Chiang, Martina Kosikova, Hang Xie, Olga Zoueva, Angelia A. Cost, Zhiping Ye, Michael J. Cooper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0b998baf6464e9c80484175ce23810f
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spelling	oai:doaj.org-article:d0b998baf6464e9c80484175ce23810f2021-12-02T15:18:52ZDifferent Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains10.1038/s41598-017-05579-42045-2322https://doaj.org/article/d0b998baf6464e9c80484175ce23810f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05579-4https://doaj.org/toc/2045-2322Abstract Seasonal influenza vaccine formulas change almost every year yet information about how this affects the antibody repertoire of vaccine recipients is inadequate. New vaccine virus strains are selected, replacing older strains to better match the currently circulating strains. But even while the vaccine is being manufactured the circulating strains can evolve. The ideal response to a seasonal vaccine would maintain antibodies toward existing strains that might continue to circulate, and to generate cross-reactive antibodies, particularly towards conserved influenza epitopes, potentially limiting infections caused by newly evolving strains. Here we use the hemagglutination inhibition assay to analyze the antibody repertoire in subjects vaccinated two years in a row with either identical vaccine virus strains or with differing vaccine virus strains. The data indicates that changing the vaccine formulation results in an antibody repertoire that is better able to react with strains emerging after the vaccine virus strains are selected. The effect is observed for both influenza A and B strains in groups of subjects vaccinated in three different seasons. Analyses include stratification by age and sex.Ewan P. PlantLucy J. FredellBlake A. HatcherXing LiMeng-Jung ChiangMartina KosikovaHang XieOlga ZouevaAngelia A. CostZhiping YeMichael J. CooperNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ewan P. Plant Lucy J. Fredell Blake A. Hatcher Xing Li Meng-Jung Chiang Martina Kosikova Hang Xie Olga Zoueva Angelia A. Cost Zhiping Ye Michael J. Cooper Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains
description	Abstract Seasonal influenza vaccine formulas change almost every year yet information about how this affects the antibody repertoire of vaccine recipients is inadequate. New vaccine virus strains are selected, replacing older strains to better match the currently circulating strains. But even while the vaccine is being manufactured the circulating strains can evolve. The ideal response to a seasonal vaccine would maintain antibodies toward existing strains that might continue to circulate, and to generate cross-reactive antibodies, particularly towards conserved influenza epitopes, potentially limiting infections caused by newly evolving strains. Here we use the hemagglutination inhibition assay to analyze the antibody repertoire in subjects vaccinated two years in a row with either identical vaccine virus strains or with differing vaccine virus strains. The data indicates that changing the vaccine formulation results in an antibody repertoire that is better able to react with strains emerging after the vaccine virus strains are selected. The effect is observed for both influenza A and B strains in groups of subjects vaccinated in three different seasons. Analyses include stratification by age and sex.
format	article
author	Ewan P. Plant Lucy J. Fredell Blake A. Hatcher Xing Li Meng-Jung Chiang Martina Kosikova Hang Xie Olga Zoueva Angelia A. Cost Zhiping Ye Michael J. Cooper
author_facet	Ewan P. Plant Lucy J. Fredell Blake A. Hatcher Xing Li Meng-Jung Chiang Martina Kosikova Hang Xie Olga Zoueva Angelia A. Cost Zhiping Ye Michael J. Cooper
author_sort	Ewan P. Plant
title	Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains
title_short	Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains
title_full	Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains
title_fullStr	Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains
title_full_unstemmed	Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains
title_sort	different repeat annual influenza vaccinations improve the antibody response to drifted influenza strains
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d0b998baf6464e9c80484175ce23810f
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Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains

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