The native ORAI channel trio underlies the diversity of Ca2+ signaling events

The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood, but the roles of ORAI2 and ORAI3 remained obscure. Here authors show that ORAI2 and ORAI3 channels multimerize with ORAI1 to expand the range of sensitivity of receptor-activated Ca2+ signals, reflecting their...

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Autores principales:	Ryan E. Yoast, Scott M. Emrich, Xuexin Zhang, Ping Xin, Martin T. Johnson, Adam J. Fike, Vonn Walter, Nadine Hempel, David I. Yule, James Sneyd, Donald L. Gill, Mohamed Trebak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0bad2674967414e8be76ad70168e97d
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spelling	oai:doaj.org-article:d0bad2674967414e8be76ad70168e97d2021-12-02T17:15:59ZThe native ORAI channel trio underlies the diversity of Ca2+ signaling events10.1038/s41467-020-16232-62041-1723https://doaj.org/article/d0bad2674967414e8be76ad70168e97d2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16232-6https://doaj.org/toc/2041-1723The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood, but the roles of ORAI2 and ORAI3 remained obscure. Here authors show that ORAI2 and ORAI3 channels multimerize with ORAI1 to expand the range of sensitivity of receptor-activated Ca2+ signals, reflecting their enhanced basal STIM1-binding and heightened Ca2+-dependent inactivation.Ryan E. YoastScott M. EmrichXuexin ZhangPing XinMartin T. JohnsonAdam J. FikeVonn WalterNadine HempelDavid I. YuleJames SneydDonald L. GillMohamed TrebakNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryan E. Yoast Scott M. Emrich Xuexin Zhang Ping Xin Martin T. Johnson Adam J. Fike Vonn Walter Nadine Hempel David I. Yule James Sneyd Donald L. Gill Mohamed Trebak The native ORAI channel trio underlies the diversity of Ca2+ signaling events
description	The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood, but the roles of ORAI2 and ORAI3 remained obscure. Here authors show that ORAI2 and ORAI3 channels multimerize with ORAI1 to expand the range of sensitivity of receptor-activated Ca2+ signals, reflecting their enhanced basal STIM1-binding and heightened Ca2+-dependent inactivation.
format	article
author	Ryan E. Yoast Scott M. Emrich Xuexin Zhang Ping Xin Martin T. Johnson Adam J. Fike Vonn Walter Nadine Hempel David I. Yule James Sneyd Donald L. Gill Mohamed Trebak
author_facet	Ryan E. Yoast Scott M. Emrich Xuexin Zhang Ping Xin Martin T. Johnson Adam J. Fike Vonn Walter Nadine Hempel David I. Yule James Sneyd Donald L. Gill Mohamed Trebak
author_sort	Ryan E. Yoast
title	The native ORAI channel trio underlies the diversity of Ca2+ signaling events
title_short	The native ORAI channel trio underlies the diversity of Ca2+ signaling events
title_full	The native ORAI channel trio underlies the diversity of Ca2+ signaling events
title_fullStr	The native ORAI channel trio underlies the diversity of Ca2+ signaling events
title_full_unstemmed	The native ORAI channel trio underlies the diversity of Ca2+ signaling events
title_sort	native orai channel trio underlies the diversity of ca2+ signaling events
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d0bad2674967414e8be76ad70168e97d
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The native ORAI channel trio underlies the diversity of Ca2+ signaling events

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