Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis

Abstract Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and o...

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Autores principales: Reas S. Khan, Bailey Baumann, Kimberly Dine, Ying Song, Joshua L. Dunaief, Sangwon F. Kim, Kenneth S. Shindler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d0bc350eede54e77b57423da0e937210
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