Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study

Background: Brass is a copper-zinc alloy that also contains additional elements, including lead. Industrial operations on brass produce dust and fumes that can be harmful to an individual’s health. Ayurveda recommends Dadima Svarasa and Triphala Churna for the management of symptoms caused due to br...

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Autores principales:	Vivek Kumar Patel, Kalpesh Panara, Rabinarayan Acharya
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Brass Copper Heavy metal poisoning Lead Pomegranate Triphala Miscellaneous systems and treatments RZ409.7-999
Acceso en línea:	https://doaj.org/article/d0bee6a946d748658fb9b0020ec27eaf
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spelling	oai:doaj.org-article:d0bee6a946d748658fb9b0020ec27eaf2021-12-02T04:59:21ZAyurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study0975-947610.1016/j.jaim.2021.06.020https://doaj.org/article/d0bee6a946d748658fb9b0020ec27eaf2021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0975947621001285https://doaj.org/toc/0975-9476Background: Brass is a copper-zinc alloy that also contains additional elements, including lead. Industrial operations on brass produce dust and fumes that can be harmful to an individual’s health. Ayurveda recommends Dadima Svarasa and Triphala Churna for the management of symptoms caused due to brass toxicity. Objective: To obtain preliminary evidence on the efficacy of Triphala Churna (powder mixture of three myrobalans) and Dadima Svarasa (pomegranate juice) in the management of brass-associated high serum level of copper, zinc, lead, and their harms through an open-label single-arm pilot study. Materials and methods: A total of 20 workers with brass toxicity and increased level of one or more of the serum ions including copper, zinc and lead were prescribed. 5gm Triphala powder once daily and Dadima Svarasa 40 ml in two divided doses were administered daily for 28 days. Changes in serum concentration of heavy metals and common health problems like anorexia, headache, dizziness, weakness, nausea, nose irritation, eye irritation, epigastric pain, abdominal distention, chest pain, dyspnea, cough, lumbar pain, body ache, numbness, and occupational dermatitis were reported at baseline and end of the trial. Results: Trial drugs were found to produce significant decrease in mean values of serum copper (p < 0.001) and serum lead (p < 0.001) whereas significant increase in mean values of serum zinc (p > 0.001) was observed. Significant relief was observed in nausea (p = 0.005), anorexia (p = 0.000), epigastric pain (p = 0.001), abdominal distention (p = 0.014), weakness (p = 0.005) and body ache (p = 0.005). Conclusion: Triphala Churna along with Dadima Svarasa are safe and effective in the management of brass-associated high serum levels of copper and lead and their health hazards.Vivek Kumar PatelKalpesh PanaraRabinarayan AcharyaElsevierarticleBrassCopperHeavy metal poisoningLeadPomegranateTriphalaMiscellaneous systems and treatmentsRZ409.7-999ENJournal of Ayurveda and Integrative Medicine, Vol 12, Iss 4, Pp 689-694 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brass Copper Heavy metal poisoning Lead Pomegranate Triphala Miscellaneous systems and treatments RZ409.7-999
spellingShingle	Brass Copper Heavy metal poisoning Lead Pomegranate Triphala Miscellaneous systems and treatments RZ409.7-999 Vivek Kumar Patel Kalpesh Panara Rabinarayan Acharya Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study
description	Background: Brass is a copper-zinc alloy that also contains additional elements, including lead. Industrial operations on brass produce dust and fumes that can be harmful to an individual’s health. Ayurveda recommends Dadima Svarasa and Triphala Churna for the management of symptoms caused due to brass toxicity. Objective: To obtain preliminary evidence on the efficacy of Triphala Churna (powder mixture of three myrobalans) and Dadima Svarasa (pomegranate juice) in the management of brass-associated high serum level of copper, zinc, lead, and their harms through an open-label single-arm pilot study. Materials and methods: A total of 20 workers with brass toxicity and increased level of one or more of the serum ions including copper, zinc and lead were prescribed. 5gm Triphala powder once daily and Dadima Svarasa 40 ml in two divided doses were administered daily for 28 days. Changes in serum concentration of heavy metals and common health problems like anorexia, headache, dizziness, weakness, nausea, nose irritation, eye irritation, epigastric pain, abdominal distention, chest pain, dyspnea, cough, lumbar pain, body ache, numbness, and occupational dermatitis were reported at baseline and end of the trial. Results: Trial drugs were found to produce significant decrease in mean values of serum copper (p < 0.001) and serum lead (p < 0.001) whereas significant increase in mean values of serum zinc (p > 0.001) was observed. Significant relief was observed in nausea (p = 0.005), anorexia (p = 0.000), epigastric pain (p = 0.001), abdominal distention (p = 0.014), weakness (p = 0.005) and body ache (p = 0.005). Conclusion: Triphala Churna along with Dadima Svarasa are safe and effective in the management of brass-associated high serum levels of copper and lead and their health hazards.
format	article
author	Vivek Kumar Patel Kalpesh Panara Rabinarayan Acharya
author_facet	Vivek Kumar Patel Kalpesh Panara Rabinarayan Acharya
author_sort	Vivek Kumar Patel
title	Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study
title_short	Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study
title_full	Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study
title_fullStr	Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study
title_full_unstemmed	Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study
title_sort	ayurveda intervention for brass-induced heavy metal toxicity: a report from the single-arm pilot study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d0bee6a946d748658fb9b0020ec27eaf
work_keys_str_mv	AT vivekkumarpatel ayurvedainterventionforbrassinducedheavymetaltoxicityareportfromthesinglearmpilotstudy AT kalpeshpanara ayurvedainterventionforbrassinducedheavymetaltoxicityareportfromthesinglearmpilotstudy AT rabinarayanacharya ayurvedainterventionforbrassinducedheavymetaltoxicityareportfromthesinglearmpilotstudy
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Ayurveda intervention for brass-induced heavy metal toxicity: A report from the single-arm pilot study

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