Role of the Discriminator Sequence in the Supercoiling Sensitivity of Bacterial Promoters

In this study, we highlight the role of the discriminator as a global sensor of supercoiling variations and propose the first quantitative regulatory model of this principle, based on the specific step of promoter opening during transcription initiation. It defines the predictive rule by which SC q...

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Auteurs principaux: Raphaël Forquet, Maïwenn Pineau, William Nasser, Sylvie Reverchon, Sam Meyer
Format: article
Langue:EN
Publié: American Society for Microbiology 2021
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Accès en ligne:https://doaj.org/article/d0bf0838a738433d8d5e1ede648a5d8f
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