Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration

Abstract One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma...

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Autores principales:	Anselmo Moriscot, Elen H. Miyabara, Bruno Langeani, Antonio Belli, Stuart Egginton, T. Scott Bowen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/d0bfc0cd1d7d45ddb22bc0e83d0de854
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spelling	oai:doaj.org-article:d0bfc0cd1d7d45ddb22bc0e83d0de8542021-12-02T11:44:51ZFirearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration10.1038/s41536-021-00127-12057-3995https://doaj.org/article/d0bfc0cd1d7d45ddb22bc0e83d0de8542021-03-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00127-1https://doaj.org/toc/2057-3995Abstract One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma include soft-tissue damage and loss, haemorrhage, bone fracture, and pain. The majority of injuries are of musculoskeletal origin and located in the extremities, such that skeletal muscle offers a major therapeutic target to aid recovery and return to normal daily activities. However, the underlying pathophysiology of skeletal muscle ballistic trauma remains poorly understood, with limited evidence-based treatment options. As such, this review will address the topic of firearm-related skeletal muscle injury and regeneration. We first introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. Finally, we evaluate novel approaches for minimising muscle damage and enhancing muscle regeneration after ballistic trauma, which may have important relevance for primary care in victims of violence.Anselmo MoriscotElen H. MiyabaraBruno LangeaniAntonio BelliStuart EggintonT. Scott BowenNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Anselmo Moriscot Elen H. Miyabara Bruno Langeani Antonio Belli Stuart Egginton T. Scott Bowen Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
description	Abstract One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma include soft-tissue damage and loss, haemorrhage, bone fracture, and pain. The majority of injuries are of musculoskeletal origin and located in the extremities, such that skeletal muscle offers a major therapeutic target to aid recovery and return to normal daily activities. However, the underlying pathophysiology of skeletal muscle ballistic trauma remains poorly understood, with limited evidence-based treatment options. As such, this review will address the topic of firearm-related skeletal muscle injury and regeneration. We first introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. Finally, we evaluate novel approaches for minimising muscle damage and enhancing muscle regeneration after ballistic trauma, which may have important relevance for primary care in victims of violence.
format	article
author	Anselmo Moriscot Elen H. Miyabara Bruno Langeani Antonio Belli Stuart Egginton T. Scott Bowen
author_facet	Anselmo Moriscot Elen H. Miyabara Bruno Langeani Antonio Belli Stuart Egginton T. Scott Bowen
author_sort	Anselmo Moriscot
title	Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
title_short	Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
title_full	Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
title_fullStr	Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
title_full_unstemmed	Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
title_sort	firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d0bfc0cd1d7d45ddb22bc0e83d0de854
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Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration

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