Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma

Renal cell carcinoma is the third most common urological cancer. Despite recent advances, late diagnosis and poor prognosis of advanced-stage disease remain a major problem, entailing the need for novel early diagnosis tools. Liquid biopsies represent a promising minimally invasive clinical tool, pr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	José Pedro Sequeira, Vera Constâncio, João Lobo, Rui Henrique, Carmen Jerónimo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	renal cell carcinoma biomarkers liquid biopsies microRNA extracellular vesicles exosomes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d0bff859876a4b40abd76ec2c117efb4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d0bff859876a4b40abd76ec2c117efb4
record_format	dspace
spelling	oai:doaj.org-article:d0bff859876a4b40abd76ec2c117efb42021-11-11T15:26:26ZUnveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma10.3390/cancers132152522072-6694https://doaj.org/article/d0bff859876a4b40abd76ec2c117efb42021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5252https://doaj.org/toc/2072-6694Renal cell carcinoma is the third most common urological cancer. Despite recent advances, late diagnosis and poor prognosis of advanced-stage disease remain a major problem, entailing the need for novel early diagnosis tools. Liquid biopsies represent a promising minimally invasive clinical tool, providing real-time feedback of tumor behavior and biological potential, addressing its clonal evolution and representing its heterogeneity. In particular, the study of circulating microRNAs and exosomal microRNAs in liquid biopsies experienced an exponential increase in recent years, considering the potential clinical utility and available technology that facilitates implementation. Herein, we provide a systematic review on the applicability of these biomarkers in the context of renal cell carcinoma. Issues such as additional benefit from extracting microRNAs transported in extracellular vesicles, use for subtyping and representation of different histological types, correlation with tumor burden, and prediction of patient outcome are also addressed. Despite the need for more conclusive research, available data indicate that exosomal microRNAs represent a robust minimally invasive biomarker for renal cell carcinoma. Thus, innovative research on microRNAs and novel detection techniques are likely to provide clinically relevant biomarkers, overcome current clinical challenges, and improve patient management.José Pedro SequeiraVera ConstâncioJoão LoboRui HenriqueCarmen JerónimoMDPI AGarticlerenal cell carcinomabiomarkersliquid biopsiesmicroRNAextracellular vesiclesexosomesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5252, p 5252 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal cell carcinoma biomarkers liquid biopsies microRNA extracellular vesicles exosomes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	renal cell carcinoma biomarkers liquid biopsies microRNA extracellular vesicles exosomes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 José Pedro Sequeira Vera Constâncio João Lobo Rui Henrique Carmen Jerónimo Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma
description	Renal cell carcinoma is the third most common urological cancer. Despite recent advances, late diagnosis and poor prognosis of advanced-stage disease remain a major problem, entailing the need for novel early diagnosis tools. Liquid biopsies represent a promising minimally invasive clinical tool, providing real-time feedback of tumor behavior and biological potential, addressing its clonal evolution and representing its heterogeneity. In particular, the study of circulating microRNAs and exosomal microRNAs in liquid biopsies experienced an exponential increase in recent years, considering the potential clinical utility and available technology that facilitates implementation. Herein, we provide a systematic review on the applicability of these biomarkers in the context of renal cell carcinoma. Issues such as additional benefit from extracting microRNAs transported in extracellular vesicles, use for subtyping and representation of different histological types, correlation with tumor burden, and prediction of patient outcome are also addressed. Despite the need for more conclusive research, available data indicate that exosomal microRNAs represent a robust minimally invasive biomarker for renal cell carcinoma. Thus, innovative research on microRNAs and novel detection techniques are likely to provide clinically relevant biomarkers, overcome current clinical challenges, and improve patient management.
format	article
author	José Pedro Sequeira Vera Constâncio João Lobo Rui Henrique Carmen Jerónimo
author_facet	José Pedro Sequeira Vera Constâncio João Lobo Rui Henrique Carmen Jerónimo
author_sort	José Pedro Sequeira
title	Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma
title_short	Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma
title_full	Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma
title_fullStr	Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma
title_full_unstemmed	Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma
title_sort	unveiling the world of circulating and exosomal micrornas in renal cell carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d0bff859876a4b40abd76ec2c117efb4
work_keys_str_mv	AT josepedrosequeira unveilingtheworldofcirculatingandexosomalmicrornasinrenalcellcarcinoma AT veraconstancio unveilingtheworldofcirculatingandexosomalmicrornasinrenalcellcarcinoma AT joaolobo unveilingtheworldofcirculatingandexosomalmicrornasinrenalcellcarcinoma AT ruihenrique unveilingtheworldofcirculatingandexosomalmicrornasinrenalcellcarcinoma AT carmenjeronimo unveilingtheworldofcirculatingandexosomalmicrornasinrenalcellcarcinoma
_version_	1718435337093513216

Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma

Ejemplares similares