Cooperative transport mechanism of human monocarboxylate transporter 2

Cooperative transport mechanism of human monocarboxylate transporter 2

Proton-linked monocarboxylate transporters (MCTs) facilitate monocarboxylate efflux in glycolytically active cells and regulate transport down in glycolytically inactive cells. Here authors show a steep dependence of human MCT2 activity on substrate concentration and show the structural basis of coo...

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Autores principales: Bo Zhang, Qiuheng Jin, Lizhen Xu, Ningning Li, Ying Meng, Shenghai Chang, Xiang Zheng, Jiangqin Wang, Yuan Chen, Dante Neculai, Ning Gao, Xiaokang Zhang, Fan Yang, Jiangtao Guo, Sheng Ye
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/d0c087436b35421cba015b279372e1cf
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Sumario:Proton-linked monocarboxylate transporters (MCTs) facilitate monocarboxylate efflux in glycolytically active cells and regulate transport down in glycolytically inactive cells. Here authors show a steep dependence of human MCT2 activity on substrate concentration and show the structural basis of cooperative transport.

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