Cooperative transport mechanism of human monocarboxylate transporter 2

Proton-linked monocarboxylate transporters (MCTs) facilitate monocarboxylate efflux in glycolytically active cells and regulate transport down in glycolytically inactive cells. Here authors show a steep dependence of human MCT2 activity on substrate concentration and show the structural basis of coo...

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Autores principales:	Bo Zhang, Qiuheng Jin, Lizhen Xu, Ningning Li, Ying Meng, Shenghai Chang, Xiang Zheng, Jiangqin Wang, Yuan Chen, Dante Neculai, Ning Gao, Xiaokang Zhang, Fan Yang, Jiangtao Guo, Sheng Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0c087436b35421cba015b279372e1cf
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spelling	oai:doaj.org-article:d0c087436b35421cba015b279372e1cf2021-12-02T16:50:26ZCooperative transport mechanism of human monocarboxylate transporter 210.1038/s41467-020-16334-12041-1723https://doaj.org/article/d0c087436b35421cba015b279372e1cf2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16334-1https://doaj.org/toc/2041-1723Proton-linked monocarboxylate transporters (MCTs) facilitate monocarboxylate efflux in glycolytically active cells and regulate transport down in glycolytically inactive cells. Here authors show a steep dependence of human MCT2 activity on substrate concentration and show the structural basis of cooperative transport.Bo ZhangQiuheng JinLizhen XuNingning LiYing MengShenghai ChangXiang ZhengJiangqin WangYuan ChenDante NeculaiNing GaoXiaokang ZhangFan YangJiangtao GuoSheng YeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Zhang Qiuheng Jin Lizhen Xu Ningning Li Ying Meng Shenghai Chang Xiang Zheng Jiangqin Wang Yuan Chen Dante Neculai Ning Gao Xiaokang Zhang Fan Yang Jiangtao Guo Sheng Ye Cooperative transport mechanism of human monocarboxylate transporter 2
description	Proton-linked monocarboxylate transporters (MCTs) facilitate monocarboxylate efflux in glycolytically active cells and regulate transport down in glycolytically inactive cells. Here authors show a steep dependence of human MCT2 activity on substrate concentration and show the structural basis of cooperative transport.
format	article
author	Bo Zhang Qiuheng Jin Lizhen Xu Ningning Li Ying Meng Shenghai Chang Xiang Zheng Jiangqin Wang Yuan Chen Dante Neculai Ning Gao Xiaokang Zhang Fan Yang Jiangtao Guo Sheng Ye
author_facet	Bo Zhang Qiuheng Jin Lizhen Xu Ningning Li Ying Meng Shenghai Chang Xiang Zheng Jiangqin Wang Yuan Chen Dante Neculai Ning Gao Xiaokang Zhang Fan Yang Jiangtao Guo Sheng Ye
author_sort	Bo Zhang
title	Cooperative transport mechanism of human monocarboxylate transporter 2
title_short	Cooperative transport mechanism of human monocarboxylate transporter 2
title_full	Cooperative transport mechanism of human monocarboxylate transporter 2
title_fullStr	Cooperative transport mechanism of human monocarboxylate transporter 2
title_full_unstemmed	Cooperative transport mechanism of human monocarboxylate transporter 2
title_sort	cooperative transport mechanism of human monocarboxylate transporter 2
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d0c087436b35421cba015b279372e1cf
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_version_	1718383067239809024

Cooperative transport mechanism of human monocarboxylate transporter 2

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