Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors

Mike Briley, Chantal MoretNeuroBiz Consulting and Communication, Castres, FranceAbstract: Depression is a disabling condition resulting in significant impairment in social functioning, involving the patient&rsquo;s family, friends, work colleagues, and society at large. Although both psychol...

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Autores principales:	Mike Briley, Chantal Moret
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d0c094b93a334ae497492f4fa3bd0f71
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spelling	oai:doaj.org-article:d0c094b93a334ae497492f4fa3bd0f712021-12-02T00:27:03ZImprovement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors1176-63281178-2021https://doaj.org/article/d0c094b93a334ae497492f4fa3bd0f712010-09-01T00:00:00Zhttp://www.dovepress.com/improvement-of-social-adaptation-in-depression-with-serotonin-and-nore-a5355https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Mike Briley, Chantal MoretNeuroBiz Consulting and Communication, Castres, FranceAbstract: Depression is a disabling condition resulting in significant impairment in social functioning, involving the patient&rsquo;s family, friends, work colleagues, and society at large. Although both psychologic and pharmacologic treatments generally improve many depressive symptoms, they do not always result in significant improvement in social functioning. The importance of recovery of social functioning in depressed patients is now widely appreciated, and studies are beginning to include it in evaluations of therapeutic efficacy. Among the various social adjustment evaluation rating scales, the Social Adaptation Self-Evaluation Scale, a social motivation and behavior scale, has been found to be simple to use and sensitive to change. Using this scale, the selective norepinephrine reuptake inhibitor, reboxetine, has been shown to be significantly more effective in improving social functioning than the selective serotonin reuptake inhibitor, fluoxetine. These findings are consistent with the notion that improvement in social adaptation involves functions depending primarily on noradrenergic neurotransmission. This hypothesis suggests that the serotonin and norepinephrine reuptake inhibitors, venlafaxine, duloxetine, and milnacipran, could be particularly helpful in improving social functioning. Preliminary studies with the serotonin and norepinephrine reuptake inhibitors suggest that they significantly improve social functioning. Comparative studies with selective serotonin reuptake inhibitors on the effects on social functioning should be encouraged.Keywords: Social Adaptation Self-Evaluation Scale, social functioning, depression, serotonin and norepinephrine reuptake inhibitors, noradrenergic neurotransmission Mike BrileyChantal MoretDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 647-655 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Mike Briley Chantal Moret Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors
description	Mike Briley, Chantal MoretNeuroBiz Consulting and Communication, Castres, FranceAbstract: Depression is a disabling condition resulting in significant impairment in social functioning, involving the patient&rsquo;s family, friends, work colleagues, and society at large. Although both psychologic and pharmacologic treatments generally improve many depressive symptoms, they do not always result in significant improvement in social functioning. The importance of recovery of social functioning in depressed patients is now widely appreciated, and studies are beginning to include it in evaluations of therapeutic efficacy. Among the various social adjustment evaluation rating scales, the Social Adaptation Self-Evaluation Scale, a social motivation and behavior scale, has been found to be simple to use and sensitive to change. Using this scale, the selective norepinephrine reuptake inhibitor, reboxetine, has been shown to be significantly more effective in improving social functioning than the selective serotonin reuptake inhibitor, fluoxetine. These findings are consistent with the notion that improvement in social adaptation involves functions depending primarily on noradrenergic neurotransmission. This hypothesis suggests that the serotonin and norepinephrine reuptake inhibitors, venlafaxine, duloxetine, and milnacipran, could be particularly helpful in improving social functioning. Preliminary studies with the serotonin and norepinephrine reuptake inhibitors suggest that they significantly improve social functioning. Comparative studies with selective serotonin reuptake inhibitors on the effects on social functioning should be encouraged.Keywords: Social Adaptation Self-Evaluation Scale, social functioning, depression, serotonin and norepinephrine reuptake inhibitors, noradrenergic neurotransmission
format	article
author	Mike Briley Chantal Moret
author_facet	Mike Briley Chantal Moret
author_sort	Mike Briley
title	Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors
title_short	Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors
title_full	Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors
title_fullStr	Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors
title_full_unstemmed	Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors
title_sort	improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/d0c094b93a334ae497492f4fa3bd0f71
work_keys_str_mv	AT mikebriley improvementofsocialadaptationindepressionwithserotoninandnorepinephrinereuptakeinhibitors AT chantalmoret improvementofsocialadaptationindepressionwithserotoninandnorepinephrinereuptakeinhibitors
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Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors

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