Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.

Retinal synaptic connections and function are developmentally regulated. Retinal synaptic activity plays critical roles in the development of retinal synaptic circuitry. Dopamine receptors have been thought to play important roles in the activity-dependent synaptic plasticity in central nervous syst...

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Autores principales:	Quanhua He, Hong-Ping Xu, Ping Wang, Ning Tian
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0c226da03d043cb8bcf3daac7ac1806
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spelling	oai:doaj.org-article:d0c226da03d043cb8bcf3daac7ac18062021-11-18T08:45:40ZDopamine D1 receptors regulate the light dependent development of retinal synaptic responses.1932-620310.1371/journal.pone.0079625https://doaj.org/article/d0c226da03d043cb8bcf3daac7ac18062013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260267/?tool=EBIhttps://doaj.org/toc/1932-6203Retinal synaptic connections and function are developmentally regulated. Retinal synaptic activity plays critical roles in the development of retinal synaptic circuitry. Dopamine receptors have been thought to play important roles in the activity-dependent synaptic plasticity in central nervous system. The primary goal of this study is to determine whether dopamine D1 receptor regulates the activity-dependent development of retinal light responsiveness. Accordingly, we recorded electroretinogram from wild type mice and mice with genetic deletion of D1 dopamine receptor (D1-/- mice) raised under cyclic light conditions and constant darkness. Our results demonstrated that D1-/- mice have reduced amplitudes of all three major components of electroretinogram in adulthood. When the relative strength of the responses is considered, the D1-/- mice have selective reduction of the amplitudes of a-wave and oscillatory potentials evoked by low-intermediate intensities of lights. During postnatal development, D1-/- mice have increased amplitude of b-wave at the time of eye-opening but reduced developmental increase of the amplitude of b-wave after eye opening. Light deprivation from birth significantly reduced the amplitudes of b-wave and oscillatory potentials, increased the outer retinal light response gain and altered the light response kinetics of both a- and b-waves of wild type mice. In D1-/- mice, the effect of dark rearing on the amplitude of oscillatory potentials was diminished and dark rearing induced effects on the response gain of outer retina and the kinetics of a-wave were reversed. These results demonstrated roles of dopamine D1 receptor in the activity-dependent functional development of mouse retina.Quanhua HeHong-Ping XuPing WangNing TianPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79625 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Quanhua He Hong-Ping Xu Ping Wang Ning Tian Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.
description	Retinal synaptic connections and function are developmentally regulated. Retinal synaptic activity plays critical roles in the development of retinal synaptic circuitry. Dopamine receptors have been thought to play important roles in the activity-dependent synaptic plasticity in central nervous system. The primary goal of this study is to determine whether dopamine D1 receptor regulates the activity-dependent development of retinal light responsiveness. Accordingly, we recorded electroretinogram from wild type mice and mice with genetic deletion of D1 dopamine receptor (D1-/- mice) raised under cyclic light conditions and constant darkness. Our results demonstrated that D1-/- mice have reduced amplitudes of all three major components of electroretinogram in adulthood. When the relative strength of the responses is considered, the D1-/- mice have selective reduction of the amplitudes of a-wave and oscillatory potentials evoked by low-intermediate intensities of lights. During postnatal development, D1-/- mice have increased amplitude of b-wave at the time of eye-opening but reduced developmental increase of the amplitude of b-wave after eye opening. Light deprivation from birth significantly reduced the amplitudes of b-wave and oscillatory potentials, increased the outer retinal light response gain and altered the light response kinetics of both a- and b-waves of wild type mice. In D1-/- mice, the effect of dark rearing on the amplitude of oscillatory potentials was diminished and dark rearing induced effects on the response gain of outer retina and the kinetics of a-wave were reversed. These results demonstrated roles of dopamine D1 receptor in the activity-dependent functional development of mouse retina.
format	article
author	Quanhua He Hong-Ping Xu Ping Wang Ning Tian
author_facet	Quanhua He Hong-Ping Xu Ping Wang Ning Tian
author_sort	Quanhua He
title	Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.
title_short	Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.
title_full	Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.
title_fullStr	Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.
title_full_unstemmed	Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.
title_sort	dopamine d1 receptors regulate the light dependent development of retinal synaptic responses.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d0c226da03d043cb8bcf3daac7ac1806
work_keys_str_mv	AT quanhuahe dopamined1receptorsregulatethelightdependentdevelopmentofretinalsynapticresponses AT hongpingxu dopamined1receptorsregulatethelightdependentdevelopmentofretinalsynapticresponses AT pingwang dopamined1receptorsregulatethelightdependentdevelopmentofretinalsynapticresponses AT ningtian dopamined1receptorsregulatethelightdependentdevelopmentofretinalsynapticresponses
_version_	1718421351309508608

Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses.

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