A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation

One strategy to address multidrug resistance in cancer is the development of modular methods to access bioactive scaffolds. Here, the authors report a Rh(III)-catalyzed carboxylic acid-directed C(sp 2)−H allylation and apply it to the modular synthesis of (Z)-allylic macrolides which enhance antitum...

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Autores principales:	Lu Chen, Haitian Quan, Zhongliang Xu, Hao Wang, Yuanzhi Xia, Liguang Lou, Weibo Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0c292662ec8472bacc27b7282f37c58
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id	oai:doaj.org-article:d0c292662ec8472bacc27b7282f37c58
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spelling	oai:doaj.org-article:d0c292662ec8472bacc27b7282f37c582021-12-02T15:37:20ZA modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation10.1038/s41467-020-16084-02041-1723https://doaj.org/article/d0c292662ec8472bacc27b7282f37c582020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16084-0https://doaj.org/toc/2041-1723One strategy to address multidrug resistance in cancer is the development of modular methods to access bioactive scaffolds. Here, the authors report a Rh(III)-catalyzed carboxylic acid-directed C(sp 2)−H allylation and apply it to the modular synthesis of (Z)-allylic macrolides which enhance antitumoral drug activity.Lu ChenHaitian QuanZhongliang XuHao WangYuanzhi XiaLiguang LouWeibo YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Chen Haitian Quan Zhongliang Xu Hao Wang Yuanzhi Xia Liguang Lou Weibo Yang A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation
description	One strategy to address multidrug resistance in cancer is the development of modular methods to access bioactive scaffolds. Here, the authors report a Rh(III)-catalyzed carboxylic acid-directed C(sp 2)−H allylation and apply it to the modular synthesis of (Z)-allylic macrolides which enhance antitumoral drug activity.
format	article
author	Lu Chen Haitian Quan Zhongliang Xu Hao Wang Yuanzhi Xia Liguang Lou Weibo Yang
author_facet	Lu Chen Haitian Quan Zhongliang Xu Hao Wang Yuanzhi Xia Liguang Lou Weibo Yang
author_sort	Lu Chen
title	A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation
title_short	A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation
title_full	A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation
title_fullStr	A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation
title_full_unstemmed	A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation
title_sort	modular biomimetic strategy for the synthesis of macrolide p-glycoprotein inhibitors via rh-catalyzed c-h activation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d0c292662ec8472bacc27b7282f37c58
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A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation

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