A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation

A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation

One strategy to address multidrug resistance in cancer is the development of modular methods to access bioactive scaffolds. Here, the authors report a Rh(III)-catalyzed carboxylic acid-directed C(sp 2)−H allylation and apply it to the modular synthesis of (Z)-allylic macrolides which enhance antitum...

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Autores principales: Lu Chen, Haitian Quan, Zhongliang Xu, Hao Wang, Yuanzhi Xia, Liguang Lou, Weibo Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d0c292662ec8472bacc27b7282f37c58
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