Bacteriophages as potential new mammalian pathogens

Abstract Increased intestinal permeability and translocation of gut bacteria trigger various polyaetiological diseases associated with chronic inflammation and underlie a variety of poorly treatable pathologies. Previous studies have established a primary role of the microbiota composition and intes...

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Autores principales:	George V. Tetz, Kelly V. Ruggles, Hua Zhou, Adriana Heguy, Aristotelis Tsirigos, Victor Tetz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0c453ae3b8e430eb3fcc548e4822055
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spelling	oai:doaj.org-article:d0c453ae3b8e430eb3fcc548e48220552021-12-02T12:31:55ZBacteriophages as potential new mammalian pathogens10.1038/s41598-017-07278-62045-2322https://doaj.org/article/d0c453ae3b8e430eb3fcc548e48220552017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07278-6https://doaj.org/toc/2045-2322Abstract Increased intestinal permeability and translocation of gut bacteria trigger various polyaetiological diseases associated with chronic inflammation and underlie a variety of poorly treatable pathologies. Previous studies have established a primary role of the microbiota composition and intestinal permeability in such pathologies. Using a rat model, we examined the effects of exposure to a bacteriophage cocktail on intestinal permeability and relative abundance of taxonomic units in the gut bacterial community. There was an increase in markers of impaired gut permeability, such as the lactulose/mannitol ratio, plasma endotoxin concentrations, and serum levels of inflammation-related cytokines, following the bacteriophage challenge. We observed significant differences in the alpha diversity of faecal bacterial species and found that richness and diversity index values increased following the bacteriophage challenge. There was a reduction in the abundance of Blautia, Catenibacterium, Lactobacillus, and Faecalibacterium species and an increase in Butyrivibrio, Oscillospira and Ruminococcus after bacteriophage administration. These findings provide novel insights into the role of bacteriophages as potentially pathogenic for mammals and their possible implication in the development of diseases associated with increased intestinal permeability.George V. TetzKelly V. RugglesHua ZhouAdriana HeguyAristotelis TsirigosVictor TetzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q George V. Tetz Kelly V. Ruggles Hua Zhou Adriana Heguy Aristotelis Tsirigos Victor Tetz Bacteriophages as potential new mammalian pathogens
description	Abstract Increased intestinal permeability and translocation of gut bacteria trigger various polyaetiological diseases associated with chronic inflammation and underlie a variety of poorly treatable pathologies. Previous studies have established a primary role of the microbiota composition and intestinal permeability in such pathologies. Using a rat model, we examined the effects of exposure to a bacteriophage cocktail on intestinal permeability and relative abundance of taxonomic units in the gut bacterial community. There was an increase in markers of impaired gut permeability, such as the lactulose/mannitol ratio, plasma endotoxin concentrations, and serum levels of inflammation-related cytokines, following the bacteriophage challenge. We observed significant differences in the alpha diversity of faecal bacterial species and found that richness and diversity index values increased following the bacteriophage challenge. There was a reduction in the abundance of Blautia, Catenibacterium, Lactobacillus, and Faecalibacterium species and an increase in Butyrivibrio, Oscillospira and Ruminococcus after bacteriophage administration. These findings provide novel insights into the role of bacteriophages as potentially pathogenic for mammals and their possible implication in the development of diseases associated with increased intestinal permeability.
format	article
author	George V. Tetz Kelly V. Ruggles Hua Zhou Adriana Heguy Aristotelis Tsirigos Victor Tetz
author_facet	George V. Tetz Kelly V. Ruggles Hua Zhou Adriana Heguy Aristotelis Tsirigos Victor Tetz
author_sort	George V. Tetz
title	Bacteriophages as potential new mammalian pathogens
title_short	Bacteriophages as potential new mammalian pathogens
title_full	Bacteriophages as potential new mammalian pathogens
title_fullStr	Bacteriophages as potential new mammalian pathogens
title_full_unstemmed	Bacteriophages as potential new mammalian pathogens
title_sort	bacteriophages as potential new mammalian pathogens
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d0c453ae3b8e430eb3fcc548e4822055
work_keys_str_mv	AT georgevtetz bacteriophagesaspotentialnewmammalianpathogens AT kellyvruggles bacteriophagesaspotentialnewmammalianpathogens AT huazhou bacteriophagesaspotentialnewmammalianpathogens AT adrianaheguy bacteriophagesaspotentialnewmammalianpathogens AT aristotelistsirigos bacteriophagesaspotentialnewmammalianpathogens AT victortetz bacteriophagesaspotentialnewmammalianpathogens
_version_	1718394244881711104

Bacteriophages as potential new mammalian pathogens

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